(2S-trans)-4-Hydroxy-N-2-naphthylpyrrolidine-2-carboxamide

Base Information

• Chemical Name: (2S-trans)-4-Hydroxy-N-2-naphthylpyrrolidine-2-carboxamide
• CAS No.: 3326-64-5
• Molecular Formula: C15H16 N2 O2
• Molecular Weight: 256.304
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID50954903
• Mol file: 3326-64-5.mol

Synonyms:N-(4-hydroxynaphthalen-2-yl)pyrrolidine-2-carboxamide;(2S-trans)-4-Hydroxy-N-2-naphthylpyrrolidine-2-carboxamide;DTXSID50954903;N-(4-Hydroxynaphthalen-2-yl)pyrrolidine-2-carboximidic acid

Chemical Property of (2S-trans)-4-Hydroxy-N-2-naphthylpyrrolidine-2-carboxamide

Chemical Property:

• Vapor Pressure: 7.68E-13mmHg at 25°C
• Boiling Point: 553.1°Cat760mmHg
• PKA: 14.17±0.40(Predicted)
• Flash Point: 288.3°C
• PSA: 61.36000
• Density: 1.308g/cm³
• LogP: 1.90290
• Storage Temp.: −20°C
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 256.121177757
• Heavy Atom Count: 19
• Complexity: 334

Purity/Quality:

98%Min ^*data from raw suppliers

trans-4-Hydroxy-L-proline β-naphthylamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 40
• Safety Statements: 22-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CC(NC1)C(=O)NC2=CC3=CC=CC=C3C(=C2)O
• Uses: H-HYP-BETANA is used for colorimetric determination of peptidase activity in bacteria Used for colorimetric determination of peptidase activity in bacteria.

Technology Process of (2S-trans)-4-Hydroxy-N-2-naphthylpyrrolidine-2-carboxamide

There total 3 articles about (2S-trans)-4-Hydroxy-N-2-naphthylpyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-1-benzyloxycarbonyl-4-hydroxy-L-proline-[2]naphthylamide (95433-25-3) → trans-4-hydroxy-L-proline-[2]naphthylamide (3326-64-5)

Guidance literature:

With hydrogenchloride; palladium; Hydrogenation;

Reference yield:

naphthalen-2-ylamine (91-59-8) → trans-4-hydroxy-L-proline-[2]naphthylamide (3326-64-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide; THF

2: palladium; aqueous HCl / Hydrogenation

With tetrahydrofuran; hydrogenchloride; palladium; dicyclohexyl-carbodiimide;

Reference yield:

(2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid (13504-85-3) → trans-4-hydroxy-L-proline-[2]naphthylamide (3326-64-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide; THF

2: palladium; aqueous HCl / Hydrogenation

With tetrahydrofuran; hydrogenchloride; palladium; dicyclohexyl-carbodiimide;

upstream raw materials:

trans-1-benzyloxycarbonyl-4-hydroxy-L-proline-[2]naphthylamide

naphthalen-2-ylamine

(2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

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