3H-Pyrazolo[3,4-c]isoquinoline, 3-(1,1-dimethylethyl)-6-fluoro-9-methoxy-1-methyl-5-[3-methyl-4-(phenyl methoxy)phenyl]-8-[(1-methyl-4-piperidinyl)methoxy]-

Base Information

Chemical Name:3H-Pyrazolo[3,4-c]isoquinoline, 3-(1,1-dimethylethyl)-6-fluoro-9-methoxy-1-methyl-5-[3-methyl-4-(phenyl methoxy)phenyl]-8-[(1-methyl-4-piperidinyl)methoxy]-
CAS No.:838857-31-1
Molecular Formula:C37H43FN4O3
Molecular Weight:610.772
Hs Code.:

3H-Pyrazolo[3,4-c]isoquinoline,
3-(1,1-dimethylethyl)-6-fluoro-9-methoxy-1-methyl-5-[3-methyl-4-(phenyl
methoxy)phenyl]-8-[(1-methyl-4-piperidinyl)methoxy]-

Synonyms:

Suppliers and Price of 3H-Pyrazolo[3,4-c]isoquinoline, 3-(1,1-dimethylethyl)-6-fluoro-9-methoxy-1-methyl-5-[3-methyl-4-(phenyl methoxy)phenyl]-8-[(1-methyl-4-piperidinyl)methoxy]-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3H-Pyrazolo[3,4-c]isoquinoline, 3-(1,1-dimethylethyl)-6-fluoro-9-methoxy-1-methyl-5-[3-methyl-4-(phenyl methoxy)phenyl]-8-[(1-methyl-4-piperidinyl)methoxy]-

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Technology Process of 3H-Pyrazolo[3,4-c]isoquinoline, 3-(1,1-dimethylethyl)-6-fluoro-9-methoxy-1-methyl-5-[3-methyl-4-(phenyl methoxy)phenyl]-8-[(1-methyl-4-piperidinyl)methoxy]-

There total 14 articles about 3H-Pyrazolo[3,4-c]isoquinoline, 3-(1,1-dimethylethyl)-6-fluoro-9-methoxy-1-methyl-5-[3-methyl-4-(phenyl methoxy)phenyl]-8-[(1-methyl-4-piperidinyl)methoxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 838857-29-7
3-(1,1-dimethylethyl)-6-fluoro-1-methyl-9-(methyloxy)-5-{3-methyl-4-[(phenylmethyl)oxy]phenyl}-8-[(piperidin-4-ylmethyl)oxy]-3H-pyrazolo[3,4-c]isoquinoline

: 838857-31-1
3-(1,1-dimethylethyl)-6-fluoro-1-methyl-9-(methyloxy)-5-{3-methyl-4-[(phenylmethyl)oxy]phenyl}-8-{[(1-methylpiperidin-4-yl)methyl]oxy}-3H-pyrazolo[3,4-c]isoquinoline

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,1-dichloroethane; water; at 20 ℃; for 1h;

Reference yield:

: 838857-04-8
(6-fluoro-2,2-dimethyl-4H-1,3-benzodioxin-8-yl)methanol

: 838857-31-1
3-(1,1-dimethylethyl)-6-fluoro-1-methyl-9-(methyloxy)-5-{3-methyl-4-[(phenylmethyl)oxy]phenyl}-8-{[(1-methylpiperidin-4-yl)methyl]oxy}-3H-pyrazolo[3,4-c]isoquinoline

Guidance literature:: Multi-step reaction with 14 steps

1.1: sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide / dichloromethane; <730 ml / 0.25 h / 0 °C

2.1: 3-chloro-benzenecarboperoxoic acid / 1,1-dichloroethane / 0.33 h / 70 °C

2.2: 0.33 h / 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 1.75 h / 20 °C

4.1: hydrogenchloride; water / ethanol / 0.33 h / 85 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

6.1: thionyl chloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 0 °C

7.1: N,N-dimethyl-formamide / 2.33 h / 50 °C

8.1: sodium hydride / tetrahydrofuran / 0.25 h / 40 °C

9.1: ethanol / 16 h / 20 - 75 °C

10.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethyl acetate / 2 h / 2068.65 Torr

11.1: acetic acid / 120 °C

12.1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 90 °C

13.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C

14.1: sodium tris(acetoxy)borohydride / 1,1-dichloroethane; water / 1 h / 20 °C

With hydrogenchloride; sodium hypochlorite; thionyl chloride; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; water; hydrogen; sodium tris(acetoxy)borohydride; sodium hydride; sodium hydrogencarbonate; caesium carbonate; acetic acid; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; potassium bromide; palladium 10% on activated carbon; In tetrahydrofuran; 1,1-dichloroethane; ethanol; dichloromethane; <730 ml; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 838857-05-9
6-fluoro-2,2-dimethyl-4H-1,3-benzodioxine-8-carbaldehyde

: 838857-31-1
3-(1,1-dimethylethyl)-6-fluoro-1-methyl-9-(methyloxy)-5-{3-methyl-4-[(phenylmethyl)oxy]phenyl}-8-{[(1-methylpiperidin-4-yl)methyl]oxy}-3H-pyrazolo[3,4-c]isoquinoline

Guidance literature:: Multi-step reaction with 13 steps

1.1: 3-chloro-benzenecarboperoxoic acid / 1,1-dichloroethane / 0.33 h / 70 °C

1.2: 0.33 h / 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 1.75 h / 20 °C

3.1: hydrogenchloride; water / ethanol / 0.33 h / 85 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

5.1: thionyl chloride; N,N-dimethyl-formamide / tetrahydrofuran / 0.5 h / 0 °C

6.1: N,N-dimethyl-formamide / 2.33 h / 50 °C

7.1: sodium hydride / tetrahydrofuran / 0.25 h / 40 °C

8.1: ethanol / 16 h / 20 - 75 °C

9.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; ethyl acetate / 2 h / 2068.65 Torr

10.1: acetic acid / 120 °C

11.1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 90 °C

12.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C

13.1: sodium tris(acetoxy)borohydride / 1,1-dichloroethane; water / 1 h / 20 °C

With hydrogenchloride; thionyl chloride; water; hydrogen; sodium tris(acetoxy)borohydride; sodium hydride; caesium carbonate; acetic acid; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; 1,1-dichloroethane; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;