n-(4-Fluorophenyl)-3-hydroxynaphthalene-2-carboxamide

Base Information

Chemical Name:n-(4-Fluorophenyl)-3-hydroxynaphthalene-2-carboxamide
CAS No.:6267-93-2
Molecular Formula:C17H12FNO2
Molecular Weight:281.2811
Hs Code.:
NSC Number:37167
DSSTox Substance ID:DTXSID90284413
Nikkaji Number:J3.274.954B
Wikidata:Q82019351
ChEMBL ID:CHEMBL2204722

Synonyms:6267-93-2;n-(4-fluorophenyl)-3-hydroxynaphthalene-2-carboxamide;N-(4-Fluorophenyl)-3-hydroxy-2-naphthamide;NSC37167;CHEMBL2204722;SCHEMBL10865627;DTXSID90284413;NSC-37167;AKOS008973345;SR-01000297212;SR-01000297212-1;N~2~-(4-FLUOROPHENYL)-3-HYDROXY-2-NAPHTHAMIDE

Suppliers and Price of n-(4-Fluorophenyl)-3-hydroxynaphthalene-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of n-(4-Fluorophenyl)-3-hydroxynaphthalene-2-carboxamide

Chemical Property:

Vapor Pressure:1.24E-06mmHg at 25°C
Boiling Point:389.7°Cat760mmHg
Flash Point:189.5°C
Density:1.371g/cm³
XLogP3:4.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:281.08520679
Heavy Atom Count:21
Complexity:368

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C2C=C(C(=CC2=C1)C(=O)NC3=CC=C(C=C3)F)O

Technology Process of n-(4-Fluorophenyl)-3-hydroxynaphthalene-2-carboxamide

There total 3 articles about n-(4-Fluorophenyl)-3-hydroxynaphthalene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 371-40-4
4-fluoroaniline

: 92-70-6
3-Hydroxy-2-naphthoic acid

: 6267-93-2
N-(4-fluorophenyl)-3-hydroxynaphthalene-2-carboxamide

Guidance literature:: With phosphorus trichloride; In chlorobenzene; at 100 - 130 ℃; for 0.75h; Microwave irradiation;
DOI:10.3390/molecules18077977

Reference yield:

: 1734-00-5
3-hydroxy-2-naphthoyl chloride

: 371-40-4
4-fluoroaniline

: 6267-93-2
N-(4-fluorophenyl)-3-hydroxynaphthalene-2-carboxamide

Guidance literature:: With sodium acetate; In N,N-dimethyl-formamide; chlorobenzene; at 5 - 50 ℃;

Reference yield:

: 92-70-6
3-Hydroxy-2-naphthoic acid

: 6267-93-2
N-(4-fluorophenyl)-3-hydroxynaphthalene-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 1 h / Reflux

2: tetrahydrofuran / 1 h / Reflux

With thionyl chloride; In tetrahydrofuran;
DOI:10.1016/j.bmc.2012.09.056