2,5,9,14,18-Pentaazanonadecanedioic acid, 9,14-bis[(1,1-dimethylethoxy)carbonyl]-3-(4-hydroxyphenyl)-4-oxo-, 18-(1,1-dimethylethyl) 1-(9H-fluoren-9-ylmethyl) ester, (3R)-

Base Information

Chemical Name:2,5,9,14,18-Pentaazanonadecanedioic acid, 9,14-bis[(1,1-dimethylethoxy)carbonyl]-3-(4-hydroxyphenyl)-4-oxo-, 18-(1,1-dimethylethyl) 1-(9H-fluoren-9-ylmethyl) ester, (3R)-
CAS No.:839720-47-7
Molecular Formula:C48H67N5O10
Molecular Weight:874.087
Hs Code.:

2,5,9,14,18-Pentaazanonadecanedioic acid,
9,14-bis[(1,1-dimethylethoxy)carbonyl]-3-(4-hydroxyphenyl)-4-oxo-,
18-(1,1-dimethylethyl) 1-(9H-fluoren-9-ylmethyl) ester, (3R)-

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Chemical Property of 2,5,9,14,18-Pentaazanonadecanedioic acid, 9,14-bis[(1,1-dimethylethoxy)carbonyl]-3-(4-hydroxyphenyl)-4-oxo-, 18-(1,1-dimethylethyl) 1-(9H-fluoren-9-ylmethyl) ester, (3R)-

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Technology Process of 2,5,9,14,18-Pentaazanonadecanedioic acid, 9,14-bis[(1,1-dimethylethoxy)carbonyl]-3-(4-hydroxyphenyl)-4-oxo-, 18-(1,1-dimethylethyl) 1-(9H-fluoren-9-ylmethyl) ester, (3R)-

There total 4 articles about 2,5,9,14,18-Pentaazanonadecanedioic acid, 9,14-bis[(1,1-dimethylethoxy)carbonyl]-3-(4-hydroxyphenyl)-4-oxo-, 18-(1,1-dimethylethyl) 1-(9H-fluoren-9-ylmethyl) ester, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 114459-62-0
tri-Boc-spermine

: 839719-66-3
pentafluorophenyl D-α-[(9H-fluoren-9-ylmethoxycarbonyl)amino]-4-hydroxybenzeneethanoate

: 839720-47-7
(3-tert-butoxycarbonylamino-propyl)-[4-(tert-butoxycarbonyl-{3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-(4-hydroxy-phenyl)-acetylamino]-propyl}-amino)-butyl]-carbamic acid tert-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jm049906w

Reference yield:

: 71-44-3
Spermine

: 839720-47-7
(3-tert-butoxycarbonylamino-propyl)-[4-(tert-butoxycarbonyl-{3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-(4-hydroxy-phenyl)-acetylamino]-propyl}-amino)-butyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: CF₃COOEt / methanol / 0.5 h / 0 °C

1.2: methanol / 20 °C

1.3: aq. NaOH / methanol / 20 °C

2.1: 72 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

With ethyl trifluoroacetate,; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm049906w

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 839720-47-7
(3-tert-butoxycarbonylamino-propyl)-[4-(tert-butoxycarbonyl-{3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-(4-hydroxy-phenyl)-acetylamino]-propyl}-amino)-butyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: CF₃COOEt / methanol / 0.5 h / 0 °C

1.2: methanol / 20 °C

1.3: aq. NaOH / methanol / 20 °C

2.1: 72 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

With ethyl trifluoroacetate,; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm049906w