Tosylate of Triethylene glycol monobenzyl ether

Base Information

• Chemical Name: Tosylate of Triethylene glycol monobenzyl ether
• CAS No.: 84131-04-4
• Molecular Formula: C20H26O6S
• Molecular Weight: 394.489
• Mol file: 84131-04-4.mol

Synonyms:2-[2-[2-(benzyloxy)ethoxy]ethoxy]ethyl p-toluenesulfonate;2-(2-(2-(benzyloxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate;2-(2-(2-(benzyloxy)ethoxy)ethoxy)ethyl p-toluenesulfonate;2-[2-(2-benzyloxyethoxy)ethoxy]ethyl p-toluenesulfonate;tosyl derivative of triethylene glycol monobenzyl ether;toluene-4-sulfonic acid 2-[2-(2-benzyloxyethoxy)ethoxy]ethyl ester;

Chemical Property of Tosylate of Triethylene glycol monobenzyl ether

Chemical Property:

• PSA: 79.44000
• LogP: 4.03110

Purity/Quality:

98% ^*data from raw suppliers

2-(2-(2-(benzyloxy)ethoxy)ethoxy)ethyl4-methylbenzenesulfonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Tosylate of Triethylene glycol monobenzyl ether?is a carboxylic acid derivative and can be used as a pharmaceutical intermediate.

Technology Process of Tosylate of Triethylene glycol monobenzyl ether

There total 12 articles about Tosylate of Triethylene glycol monobenzyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

triethylene glycol monobenzyl ether (55489-58-2,1201808-31-2) + p-toluenesulfonyl chloride (98-59-9) → triethylene glycol monobenzyl tosyl ether (84131-04-4)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 20h;

DOI:10.1021/jo0617464

Reference yield: 83.0%

p-toluenesulfonylanhydride (4124-41-8) + triethylene glycol monobenzyl ether (55489-58-2,1201808-31-2) → triethylene glycol monobenzyl tosyl ether (84131-04-4)

Guidance literature:

p-toluenesulfonylanhydride; triethylene glycol monobenzyl ether; In pyridine; at 5 ℃; for 5h;

With water; In pyridine; ethyl acetate; Product distribution / selectivity;

Reference yield: 64.9%

triethylene glycol monobenzyl ether (55489-58-2,1201808-31-2) + p-toluenesulfonyl chloride (98-59-9) → triethylene glycol monobenzyl tosyl ether (84131-04-4) + 1-chloro-10-phenyl-3,6,9-trioxadecane (105891-50-7)

Guidance literature:

triethylene glycol monobenzyl ether; p-toluenesulfonyl chloride; In pyridine; at 0 - 20 ℃; for 17.5h;

With water; In pyridine; ethyl acetate; Product distribution / selectivity;

upstream raw materials:

triethylene glycol monobenzyl ether

p-toluenesulfonyl chloride

benzyl chloride

2,2'-[1,2-ethanediylbis(oxy)]bisethanol

Downstream raw materials:

(11S,12S)-1,22-dibenzyloxy-11,12-O-isopropylidene-3,6,9,14,17,20-hexaoxadocosane

2-<<2-<2-(2-Benzyloxyethoxy)ethoxy>ethoxy>methyl>-15-crown-5

(2-{2-[2-(2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Pentadecafluoro-octyloxy)-ethoxy]-ethoxy}-ethoxymethyl)-benzene

(2-{2-[2-(2,2,3,3,4,4,5,5,6,6,7,7,7-Tridecafluoro-heptyloxy)-ethoxy]-ethoxy}-ethoxymethyl)-benzene