1-(4-BROMO-PHENYL)-2,2,2-TRIFLUORO-ETHYLAMINE HYDROCHLORIDE

Base Information

• Chemical Name: 1-(4-BROMO-PHENYL)-2,2,2-TRIFLUORO-ETHYLAMINE HYDROCHLORIDE
• CAS No.: 842169-72-6
• Molecular Formula: C8H7BrF3N.ClH
• Molecular Weight: 290.51
• Hs Code.: 2921499090
• Mol file: 842169-72-6.mol

Synonyms:p-bromophenyl(trichloromethyl)carbinol;1-(4-bromophenyl)-2,2,2-trifluoroethyl amine hydrochloride;1-(4-Brom-phenyl)-2,2,2-trichlor-aethanol;Trichlormethyl-(4-brom-phenyl)-carbinol;1-(4-bromophenyl)-2,2,2-trichloroethan-1-ol;1-(4-bromo-phenyl)-2,2,2-trichloro-ethanol;

Chemical Property of 1-(4-BROMO-PHENYL)-2,2,2-TRIFLUORO-ETHYLAMINE HYDROCHLORIDE

Chemical Property:

• PSA: 26.02000
• LogP: 4.51350
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Bromophenyl)-2,2,2-trifluoroethan-1-amine hydrochloride 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-BROMO-PHENYL)-2,2,2-TRIFLUORO-ETHYLAMINE HYDROCHLORIDE

There total 1 articles about 1-(4-BROMO-PHENYL)-2,2,2-TRIFLUORO-ETHYLAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4'-bromo-2,2,2-trifluoroacetophenone (16184-89-7) → [1-(4-bromophenyl)-2,2,2-trifluoroethyl]amine hydrochloride (842169-72-6,336105-43-2,842169-83-9)

Guidance literature:

4'-bromo-2,2,2-trifluoroacetophenone; With lithium hexamethyldisilazane; In tetrahydrofuran; toluene; at 20 ℃;

With sodium hydroxide; dimethylsulfide borane complex; In tetrahydrofuran; toluene; at 20 ℃;

With hydrogenchloride; In diethyl ether; toluene; at 20 ℃;

DOI:10.1021/ol047431x

Reference yield:

[1-(4-bromophenyl)-2,2,2-trifluoroethyl]amine hydrochloride (842169-72-6,336105-43-2,842169-83-9) + isobutyryl chloride (79-30-1) → N-[1-(4-bromophenyl)-2,2,2-trifluoroethyl] isobutyramide (950482-82-3)

Guidance literature:

With triethylamine; In chloroform; at 0 - 20 ℃; for 1h;

Reference yield:

[1-(4-bromophenyl)-2,2,2-trifluoroethyl]amine hydrochloride (842169-72-6,336105-43-2,842169-83-9) → N-[2,2,2-trifluoro-1-(4-formylphenyl) ethyl] isobutyramide (950482-83-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / chloroform / 1 h / 0 - 20 °C

2: sodium formate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1.5 h / 120 °C / 11251.1 Torr

With sodium formate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In chloroform; N,N-dimethyl-formamide;

upstream raw materials:

4'-bromo-2,2,2-trifluoroacetophenone

Downstream raw materials:

N-[1-(4-bromophenyl)-2,2,2-trifluoroethyl] isobutyramide

N-[2,2,2-trifluoro-1-(4-formylphenyl) ethyl] isobutyramide

N-[2,2,2-trifluoro-1-(4-hydroxyiminomethylphenyl)ethyl] isobutyramide