N-[2,2,2-trifluoro-1-(4-formylphenyl) ethyl] isobutyramide

Base Information

• Chemical Name: N-[2,2,2-trifluoro-1-(4-formylphenyl) ethyl] isobutyramide
• CAS No.: 950482-83-4
• Molecular Formula: C₁₃H₁₄F₃NO₂
• Molecular Weight: 273.255
• Mol file: 950482-83-4.mol

Synonyms:N-[2,2,2-trifluoro-1-(4-formylphenyl) ethyl] isobutyramide

Chemical Property of N-[2,2,2-trifluoro-1-(4-formylphenyl) ethyl] isobutyramide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2,2,2-trifluoro-1-(4-formylphenyl) ethyl] isobutyramide

There total 2 articles about N-[2,2,2-trifluoro-1-(4-formylphenyl) ethyl] isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[1-(4-bromophenyl)-2,2,2-trifluoroethyl] isobutyramide (950482-82-3) + carbon monoxide (201230-82-2) → N-[2,2,2-trifluoro-1-(4-formylphenyl) ethyl] isobutyramide (950482-83-4)

Guidance literature:

With sodium formate; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 120 ℃; for 1.5h; under 11251.1 Torr;

Reference yield:

[1-(4-bromophenyl)-2,2,2-trifluoroethyl]amine hydrochloride (842169-72-6,336105-43-2,842169-83-9) → N-[2,2,2-trifluoro-1-(4-formylphenyl) ethyl] isobutyramide (950482-83-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / chloroform / 1 h / 0 - 20 °C

2: sodium formate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1.5 h / 120 °C / 11251.1 Torr

With sodium formate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In chloroform; N,N-dimethyl-formamide;

Reference yield:

N-[2,2,2-trifluoro-1-(4-formylphenyl) ethyl] isobutyramide (950482-83-4) → N-[2,2,2-trifluoro-1-(4-hydroxyiminomethylphenyl)ethyl] isobutyramide (950482-84-5)

Guidance literature:

With hydroxylamine hydrochloride; In methanol; water; at 20 ℃; for 1.5h;

upstream raw materials:

N-[1-(4-bromophenyl)-2,2,2-trifluoroethyl] isobutyramide

carbon monoxide

[1-(4-bromophenyl)-2,2,2-trifluoroethyl]amine hydrochloride

Downstream raw materials:

N-[2,2,2-trifluoro-1-(4-hydroxyiminomethylphenyl)ethyl] isobutyramide