2-(4-Nitrophenyl)-1,2,3,4-tetrahydroquinazoline

Base Information

Chemical Name:2-(4-Nitrophenyl)-1,2,3,4-tetrahydroquinazoline
CAS No.:84571-09-5
Molecular Formula:C14H13N3O2
Molecular Weight:255.276
Hs Code.:
DSSTox Substance ID:DTXSID50574387
Nikkaji Number:J2.032.878I

Synonyms:2-(4-Nitrophenyl)-1,2,3,4-tetrahydroquinazoline;84571-09-5;SCHEMBL12550142;DTXSID50574387

Suppliers and Price of 2-(4-Nitrophenyl)-1,2,3,4-tetrahydroquinazoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-(4-Nitrophenyl)-1,2,3,4-tetrahydroquinazoline

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:255.100776666
Heavy Atom Count:19
Complexity:323

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C2=CC=CC=C2NC(N1)C3=CC=C(C=C3)[N+](=O)[O-]

Technology Process of 2-(4-Nitrophenyl)-1,2,3,4-tetrahydroquinazoline

There total 7 articles about 2-(4-Nitrophenyl)-1,2,3,4-tetrahydroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 555-16-8
4-nitrobenzaldehdye

: 4403-69-4
2-amino-1-benzylamine

: 84571-09-5
2-(4-nitrophenyl)-1,2,3,4-tetrahydroquinazoline

Guidance literature:: In methanol; at 20 ℃; Sealed tube;
DOI:10.1002/adsc.201700178

Reference yield:

: C₁₇H₂₀N₃O₂P

: 555-16-8
4-nitrobenzaldehdye

: 84571-09-5
2-(4-nitrophenyl)-1,2,3,4-tetrahydroquinazoline

Guidance literature:: With triethylamine; phenylacetyl chloride;
DOI:10.1016/S0040-4020(97)00855-7

Reference yield:

: 96308-13-3
2-azidobenzylamine

: 84571-09-5
2-(4-nitrophenyl)-1,2,3,4-tetrahydroquinazoline

Guidance literature:: Multi-step reaction with 3 steps

1: MgSO₄ / diethyl ether / 12 h / 20 °C

2: toluene / 0.5 h / 20 °C

3: phenacetyl chloride; Et₃N

With magnesium sulfate; triethylamine; phenylacetyl chloride; In diethyl ether; toluene; 1: Condensation / 2: Substitution / 3: Cyclization;
DOI:10.1016/S0040-4020(97)00855-7