2-Aminobenzylamine

Base Information

• Chemical Name: 2-Aminobenzylamine
• CAS No.: 4403-69-4
• Molecular Formula: C7H10N2
• Molecular Weight: 122.17
• Hs Code.: 2921590090
• Mol file: 4403-69-4.mol

Synonyms:benzenemethanamine, 2-amino-;

Chemical Property of 2-Aminobenzylamine

Chemical Property:

• Vapor Pressure: 0.00744mmHg at 25°C
• Melting Point: 58-61 °C(lit.)
• Refractive Index: 1.614
• Boiling Point: 269 °C at 760 mmHg
• PKA: 9.60±0.10(Predicted)
• Flash Point: 132.3 °C
• PSA: 52.04000
• Density: 1.093 g/cm³
• LogP: 2.00900
• Storage Temp.: 0-10°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Aminomethyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 22-34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Aminobenzylamine may be used:in the synthesis of 1,2,3,4-tetrahydroquinazoline oxime, via condensation reaction with 2-(naphthalen-2-yl)-2-oxoacetaldehyde oxime in the synthesis of alkyl 5H-1,4-benzodiazepine-3-carboxylatesto modify the phosphate groups on phosphoserine peptides

Technology Process of 2-Aminobenzylamine

There total 20 articles about 2-Aminobenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl N,N-dimethylcarbamate (687-48-9) + 2,4-diacetylaminotoluene (6282-12-8) → 2-amino-1-benzylamine (4403-69-4)

Guidance literature:

Reference yield: 98.0%

anthranilic acid nitrile (1885-29-6) → 2-amino-1-benzylamine (4403-69-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1002/ardp.19833160418

Reference yield: 97.5%

anthranilic acid amide (28144-70-9,88-68-6) → 2-amino-1-benzylamine (4403-69-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 52h; Heating;

DOI:10.1021/jm00185a026

upstream raw materials:

2-nitrobenzylamine

2-nitrobenzylamine hydrochloride

o-nitrobenzonitrile

anthranilic acid nitrile

Downstream raw materials:

deoxypeganine

2-(3-Nitro-phenyl)-1,2,3,4-tetrahydro-chinazolin-Hemihydrat

2-phenyl-1,2,3, 4-tetrahydroquinazoline

2-{(E)-[(2-{[(1E)-(2-hydroxyphenyl)methylene]amino}benzyl)imino]methyl}phenol

Refernces

• 1、 Aksenov, Alexander V.,Aksenov, Dmitrii A.,Aksenov, Nicolai A.,Grishin, Igor Yu.,Malyuga, Vladimir V.,Nobi, Mezvah A.,Rubin, Michael. "Electrophilically activated nitroalkanes in synthesis of 3,4-dihydroquinozalines". . . Retrieved 2021/08/03.
• 2、 Schneek?nig, Jacob,Tannert, Bianca,Hornke, Helen,Beller, Matthias,Junge, Kathrin. "Cobalt pincer complexes for catalytic reduction of nitriles to primary amines". . p. 1779 - 1783. Retrieved 2019/04/27.