N-(4-Methylbenzene-1-sulfonyl)-N-phenylacetamide

Base Information

• Chemical Name: N-(4-Methylbenzene-1-sulfonyl)-N-phenylacetamide
• CAS No.: 84672-52-6
• Molecular Formula: C15H15NO3S
• Molecular Weight: 289.355
• DSSTox Substance ID: DTXSID90528581
• Nikkaji Number: J3.418.022I
• Wikidata: Q82398331

Synonyms:N-(4-Methylbenzene-1-sulfonyl)-N-phenylacetamide;84672-52-6;N-(4-methylphenyl)sulfonyl-N-phenylacetamide;DTXSID90528581;AKOS003030275

Chemical Property of N-(4-Methylbenzene-1-sulfonyl)-N-phenylacetamide

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 289.07726451
• Heavy Atom Count: 20
• Complexity: 427

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)N(C2=CC=CC=C2)C(=O)C

Technology Process of N-(4-Methylbenzene-1-sulfonyl)-N-phenylacetamide

There total 13 articles about N-(4-Methylbenzene-1-sulfonyl)-N-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-ethynyl-N-phenyl-4-methyl-benzenesulfonamide (312329-87-6) → N-acetyl-N-phenyl-p-toluenesulfonamide (84672-52-6)

Guidance literature:

With gold(III) chloride; silver hexafluoroantimonate; In 1,2-dichloro-ethane; at 40 ℃; for 0.5h;

DOI:10.1002/ejoc.201300162

Reference yield: 95.0%

phenyl toluenesulfonamide (68-34-8) + acetic anhydride (108-24-7) → N-acetyl-N-phenyl-p-toluenesulfonamide (84672-52-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 48.25h;

DOI:10.1021/jo5011334

Reference yield: 73.0%

phenyl toluenesulfonamide (68-34-8) + acetyl chloride (75-36-5) → N-acetyl-N-phenyl-p-toluenesulfonamide (84672-52-6)

Guidance literature:

With aluminum(III) hydrogen sulfate; at 20 ℃; for 0.333333h; Neat (no solvent);

DOI:10.1016/j.tet.2009.06.112

upstream raw materials:

phenyl toluenesulfonamide

sodium acetate

acetic anhydride

N-cyano-N-phenyl-p-toluenesulfonamide

Downstream raw materials:

Acetanilid

ethyl acetoacetate

methyl 3-(N-benzyl-N-tosylamino)-2,2-dimethylpentanoate

phenyl toluenesulfonamide

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