p-Toluamidine, N-(p-chlorophenyl)-

Base Information

• Chemical Name: p-Toluamidine, N-(p-chlorophenyl)-
• CAS No.: 7118-54-9
• Molecular Formula: C₁₄H₁₃ClN₂
• Molecular Weight: 244.724
• DSSTox Substance ID: DTXSID10221380
• Mol file: 7118-54-9.mol

Synonyms:p-Toluamidine, N-(p-chlorophenyl)-;N-(p-Chlorophenyl)-p-toluamidine;7118-54-9;DTXSID10221380

Chemical Property of p-Toluamidine, N-(p-chlorophenyl)-

Chemical Property:

• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 244.0767261
• Heavy Atom Count: 17
• Complexity: 261

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C(=NC2=CC=C(C=C2)Cl)N

Technology Process of p-Toluamidine, N-(p-chlorophenyl)-

There total 4 articles about p-Toluamidine, N-(p-chlorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.6%

4-chloro-aniline (106-47-8) + para-methylbenzonitrile (104-85-8) → N-(4-chlorophenyl) 4-methylbenzamidine (7118-54-9)

Guidance literature:

With aluminum (III) chloride; at 180 - 200 ℃; for 0.333333h;

DOI:10.1002/jhet.1638

Reference yield:

C6H4ClN(2-)*2Br(1-)*2Mg(2+) + para-methylbenzonitrile (104-85-8) → N-(4-Chloro-phenyl)-4-methyl-benzamidine (7118-54-9)

Guidance literature:

In tetrahydrofuran; Yield given;

DOI:10.1246/cl.1991.1965

Reference yield:

para-methylbenzonitrile (104-85-8) → N-(4-chlorophenyl) 4-methylbenzamidine (7118-54-9)

Guidance literature:

at 190 ℃;

DOI:10.1039/jr9490000449

upstream raw materials:

para-methylbenzonitrile

4-chloro-aniline

Downstream raw materials:

6-chloro-2-(4-methylphenyl)quinazolin-4(3H)-one

6-chloro-4-phenyl-2-(p-tolyl)-quinazoline

C₇₄H₁₁ClN₂