Quinazoline, 6-chloro-2-(4-methylphenyl)-4-phenyl-

Base Information

• Chemical Name: Quinazoline, 6-chloro-2-(4-methylphenyl)-4-phenyl-
• CAS No.: 185547-80-2
• Molecular Formula: C21H15ClN2
• Molecular Weight: 330.816
• Mol file: 185547-80-2.mol

Synonyms:

Chemical Property of Quinazoline, 6-chloro-2-(4-methylphenyl)-4-phenyl-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Quinazoline, 6-chloro-2-(4-methylphenyl)-4-phenyl-

There total 2 articles about Quinazoline, 6-chloro-2-(4-methylphenyl)-4-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(4-chlorophenyl) 4-methylbenzamidine (7118-54-9) + benzaldehyde (100-52-7) → 6-chloro-4-phenyl-2-(p-tolyl)-quinazoline (185547-80-2)

Guidance literature:

With 1,10-Phenanthroline; copper(II) oxide; In toluene; at 110 ℃; for 24h;

DOI:10.1039/c4ob00569d

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → 6-chloro-4-phenyl-2-(p-tolyl)-quinazoline (185547-80-2)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(II) oxide; 1,10-Phenanthroline / toluene / 24 h / 110 °C

2: copper(II) oxide; 1,10-Phenanthroline / toluene / 24 h / 110 °C

With 1,10-Phenanthroline; copper(II) oxide; In toluene;

DOI:10.1039/c4ob00569d

upstream raw materials:

N-(4-chlorophenyl) 4-methylbenzamidine

benzaldehyde

benzyl alcohol

Refernces