N-(4-acetamidophenyl)-1,2,5-thiadiazole-3-carboxamide

Base Information

• Chemical Name: N-(4-acetamidophenyl)-1,2,5-thiadiazole-3-carboxamide
• CAS No.: 6835-91-2
• Molecular Formula: C₁₆H₁₇NO₄
• Molecular Weight: 287.315
• DSSTox Substance ID: DTXSID70352745
• Wikidata: Q82130052

Synonyms:N-(4-acetamidophenyl)-1,2,5-thiadiazole-3-carboxamide;6835-91-2;DTXSID70352745;AKOS002305762;AB00682540-01

Chemical Property of N-(4-acetamidophenyl)-1,2,5-thiadiazole-3-carboxamide

Chemical Property:

• Vapor Pressure: 7.62E-07mmHg at 25°C
• Boiling Point: 407.3°Cat760mmHg
• Flash Point: 200.1°C
• Density: 1.479g/cm³
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 262.05244675
• Heavy Atom Count: 18
• Complexity: 318

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC=C(C=C1)NC(=O)C2=NSN=C2

Technology Process of N-(4-acetamidophenyl)-1,2,5-thiadiazole-3-carboxamide

There total 90 articles about N-(4-acetamidophenyl)-1,2,5-thiadiazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.3%

(1S*,2R*,3R*)-3-phenylselanyldihydrolycorine (136612-59-4) → (±)-lycorine (476-28-8,6835-91-2,19312-40-4,66816-51-1)

Guidance literature:

With sodium periodate; In tetrahydrofuran; methanol; at 40 ℃; for 0.166667h;

DOI:10.1039/P19960000571

Reference yield: 48.4%

(1S,2S,3a1S,12bS)-2-chloro-2,3a1,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]-phenanthridin-1-yl acetate (69787-57-1) → (1aR,2a1S,11bS,11cS)-2a1,3,4,6,11b,11c-hexahydro-1aH-[1,3]dioxolo[4,5-j]oxireno[2,3-a]pyrrolo-[3,2,1-de]phenanthridine (15324-61-5) + 2-O-methyllycorine (6879-76-1) + lycorine (476-28-8,6835-91-2,19312-40-4,66816-51-1)

Guidance literature:

With potassium carbonate; In methanol; water; for 0.5h; Heating;

Reference yield:

(1S,2S,12bS,12cS)-1,2-diol-2,4,5,7,12b,12c-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine hydrochloride (2188-68-3) → lycorine (476-28-8,6835-91-2,19312-40-4,66816-51-1)

Guidance literature:

With ammonium hydroxide; In water; at 20 ℃; for 16h;

DOI:10.1021/acs.orglett.8b02562

upstream raw materials:

(1S,2S,3a⁽¹⁾S,12bS)-7-oxo-2,3a⁽¹⁾,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrole[3,2,1-de]phenanthridine-1,2-diyl diacetate

(1S,2S,3a¹S,12bS)-2-chloro-2,3a¹,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]-phenanthridin-1-yl acetate

(1aR,2a¹S,11bS,11cS)-2a¹,3,4,6,11b,11c-hexahydro-1aH-[1,3]dioxolo[4,5-j]oxireno[2,3-a]pyrrolo-[3,2,1-de]phenanthridine

(1S,2S,12bS,12cS)-1-Ol-2-chloro-2,4,5,7,12b,12c-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine

Downstream raw materials:

2-deoxylycorine

(12bS,12cS)-2,4,5,7,12b,12c-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine

(1aR,2a¹S,11bS,11cS)-2a¹,3,4,6,11b,11c-hexahydro-1aH-[1,3]dioxolo[4,5-j]oxireno[2,3-a]pyrrolo-[3,2,1-de]phenanthridine

anhydrolycorine

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