2188-68-3

Basic information

• Product Name: Lycorine hydrochloride
• Synonyms: Licorin hydrochloride;Lycorine Hydrochloride98%;Hydrochloric Lycorine;LYCORIN;(-)-LYCORINE;LYCORINE;(1S,2S,12BS,12CS)-1,2,4,5,12B,12C-HEXAHYDRO-7H-[1,3]DIOXOLO[4,5-J]PYRROLO[3,2,1-DE]PHENANTHRIDINE-1,2-DIOL;NARCISSIN(P)
• CAS NO: 2188-68-3
• Molecular Formula: C16H17NO4
• Molecular Weight: 287.31
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;Peptidyl transferaseCell Signaling and Neuroscience;Enzyme Inhibitors by Enzyme;Gene Regulation and Expression;P to;RNA-Protein Translation Inhibitors
• Mol File: 2188-68-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 206 °C
• Boiling Point: 477.4 °C at 760 mmHg
• Flash Point: 242.5 °C
• Appearance: /
• Vapor Pressure: 6.37E-10mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: Soluble in water (15 mg/ml)
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month.
• CAS DataBase Reference: Lycorine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Lycorine hydrochloride(2188-68-3)
• EPA Substance Registry System: Lycorine hydrochloride(2188-68-3)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 2188-68-3(Hazardous Substances Data)

Usage

Description

Lycorine (2188-68-3) arrests cell cycle at G2/M phase and induces apoptosis in tumor cells.1 Inhibits human enterovirus 71 replication by blocking elongation of the viral polyprotein during translation and reduces viral cytopathic effects in mice.2 Dose-dependently extends the circadian period length in mammalian cells by enhancing Bmal1 transcription.3 Selectively inhibits human ovarian cancer cell proliferation and neovascularization (IC50=1.2 μM).4?A potent SREBF chaperone (SCAP) degrader (Kd=15.24 nM) which acts via an autophagy-independent lysosomal pathway.5

Biochem/physiol Actions

A selective inhibitor of peptidyl transferase center (PTC). In HL-60 (leukemia) cells, lycorine arrests the cell cycle at G2/M and induces apoptosis by a caspase-mediated pathway.

References

Miliauskas et al. (2005), Identification of radical scavenging compounds in Rhaponticum carthamoides by means of LC-DAD-SPE-NMR; Nat. Prod., 68 168 Liu et al. (2011), Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication; Virol. J., 8 483 Onishi et al. (2012), Lycorine, a candidate for the control of period length in mammalian cells; Cell Physiol. Biochem., 29 407 Cao et al. (2013), Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity; Toxicol. Lett., 218 174 Zheng et al. (2020), The Paf1 complex transcriptionally regulates the mitochondrial anchored protein Atg32 leading to activation of mitophagy; Autophagy, 20 1

InChI:InChI=1/C16H17NO4.ClH/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19;/h3-5,11,14-16,18-19H,1-2,6-7H2;1H/t11-,14-,15+,16+;/m0./s1

Downstream Products

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