methyl 2-amino-4-hydroxy-5-methoxybenzoate

Base Information

• Chemical Name: methyl 2-amino-4-hydroxy-5-methoxybenzoate
• CAS No.: 848092-84-2
• Molecular Formula: C9H11NO4
• Molecular Weight: 197.191
• Mol file: 848092-84-2.mol

Synonyms:Benzoic acid,2-amino-4-hydroxy-5-methoxy-,methyl ester;methyl 2-amino-4-hydroxy-5-methoxy-benzoate;

Chemical Property of methyl 2-amino-4-hydroxy-5-methoxybenzoate

Chemical Property:

• PSA: 81.78000
• LogP: 1.35080

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-amino-4-hydroxy-5-methoxybenzoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 2-amino-4-hydroxy-5-methoxybenzoate

There total 6 articles about methyl 2-amino-4-hydroxy-5-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 4-(benzyloxy)-5-methoxy-2-nitrobenzoate (61032-41-5) → methyl 2-amino-4-hydroxy-5-methoxybenzoate (848092-84-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; at 20 ℃; under 750.075 Torr;

Reference yield: 92.0%

→ methyl 2-amino-4-hydroxy-5-methoxybenzoate (848092-84-2)

Guidance literature:

With boron trifluoride diethyl etherate; ethanethiol; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2006.04.025

Reference yield: 28.8%

4-hydroxy-3-methoxybenzoic acid methyl ester (3943-74-6) → methyl 2-amino-4-hydroxy-5-methoxybenzoate (848092-84-2) + 3-amino-4-hydroxy-5-methoxybenzoic acid methyl ester (92643-72-6)

Guidance literature:

With O-(4-nitrobenzoyl)hydroxylammonium trifluoromethanesulfonate; iron(II) bromide; silver(I) triflimide; In 2,2,2-trifluoroethanol; water; at 30 ℃; for 2h;

DOI:10.1002/chem.201605476

upstream raw materials:

methyl 4-(benzyloxy)-5-methoxy-2-nitrobenzoate

4-hydroxy-3-methoxybenzoic acid methyl ester

methyl 4-(benzyloxy)-3-methoxybenzoate

4-hydroxy-5-methoxy-2-nitrobenzoic acid methyl ester