4-HYDROXY-5-METHOXY-2-NITRO-BENZOIC ACID METHYL ESTER

Base Information

• Chemical Name: 4-HYDROXY-5-METHOXY-2-NITRO-BENZOIC ACID METHYL ESTER
• CAS No.: 27883-60-9
• Molecular Formula: C9H9NO6
• Molecular Weight: 227.174
• Hs Code.: 2918990090
• Mol file: 27883-60-9.mol

Synonyms:4-HYDROXY-5-METHOXY-2-NITRO-BENZOIC ACID METHYL ESTER;Methyl 4-hydroxy-5-Methoxy-2-nitrobenzoate

Chemical Property of 4-HYDROXY-5-METHOXY-2-NITRO-BENZOIC ACID METHYL ESTER

Chemical Property:

• Boiling Point: 389.2±42.0 °C(Predicted)
• PKA: 6.63±0.24(Predicted)
• PSA: 101.58000
• Density: 1.405±0.06 g/cm3(Predicted)
• LogP: 1.61880
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl4-hydroxy-5-methoxy-2-nitrobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-HYDROXY-5-METHOXY-2-NITRO-BENZOIC ACID METHYL ESTER

There total 12 articles about 4-HYDROXY-5-METHOXY-2-NITRO-BENZOIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 4-(benzyloxy)-5-methoxy-2-nitrobenzoate (61032-41-5) → 4-hydroxy-5-methoxy-2-nitrobenzoic acid methyl ester (27883-60-9)

Guidance literature:

With boron trichloride; In dichloromethane; at -78 ℃; for 3h; Inert atmosphere;

Reference yield: 83.0%

methanol (67-56-1) + 4-hydroxy-5-methoxy-2-nitrobenzoic acid (140647-01-4) → 4-hydroxy-5-methoxy-2-nitrobenzoic acid methyl ester (27883-60-9)

Guidance literature:

With thionyl chloride; at 60 ℃; for 144h; Inert atmosphere;

Reference yield:

4-hydroxy-3-methoxybenzoic acid methyl ester (3943-74-6) → 4-hydroxy-5-methoxy-2-nitrobenzoic acid methyl ester (27883-60-9)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide

2: HNO₃; AcOH

3: BCl₃ / CH₂Cl₂

With nitric acid; boron trichloride; potassium carbonate; acetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00577-2

upstream raw materials:

methyl 4-(benzyloxy)-5-methoxy-2-nitrobenzoate

4-hydroxy-3-methoxybenzoic acid methyl ester

methyl 4-(benzyloxy)-3-methoxybenzoate

bromine

Downstream raw materials:

5-methoxy-2-nitro-4-trifluoromethanesulfonyloxy-benzoic acid methyl ester

methyl 4-(N-t-butoxycarbonyl)aminopropoxy-5-methoxy-2-nitrobenzoate

methyl 2-amino-4-hydroxy-5-methoxybenzoate

2-nitro-5-methoxy-4-(2-(piperidin-1-yl)ethoxy)benzoic acid methyl ester