4-(N-Boc-amino)-1,6-heptanedioic acid

Base Information

Chemical Name:4-(N-Boc-amino)-1,6-heptanedioic acid
CAS No.:848242-88-6
Molecular Formula:C12H21NO6
Molecular Weight:275.302
Hs Code.:2924190090
Mol file:848242-88-6.mol

Synonyms:N-t-butoxycarbonyl-4-aminopimelic acid;4-tert-butoxycarbonylaminoheptanedioic acid;4-tert-Butoxycarbonylamino-heptanedioic acid;

Suppliers and Price of 4-(N-Boc-amino)-1,6-heptanedioic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
4-(N-Boc-amino)-1,6-heptanedioic acid
100 mg
$ 647.00

BroadPharm
4-(N-Boc-amino)-1,6-heptanedioicacid 97%
250 MG
$ 430.00

Total 2 raw suppliers

Chemical Property of 4-(N-Boc-amino)-1,6-heptanedioic acid

Chemical Property:

PSA：112.93000
LogP:2.00020

Purity/Quality:

99% ^*data from raw suppliers

4-(N-Boc-amino)-1,6-heptanedioic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description 4-(N-Boc-amino)-1,6-heptanedioic acid is a branched compound. It can conjugate with primary amino groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Boc can be removed under acidic condition.
Uses 4-(N-Boc-amino)-1,6-heptanedioic Acid (cas# 848242-88-6) can be used in the preparation of Trastuzumab-linked TLR-agonist-containing conjugates for targeted treatment of cancer. It is also used in the preparation of insulin analog dimers, and composition containing them or an insulin receptor partial agonist and a GLP-1 analog for treating diabetes and related disorders.

Technology Process of 4-(N-Boc-amino)-1,6-heptanedioic acid

There total 1 articles about 4-(N-Boc-amino)-1,6-heptanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7766-85-0
4-aminopimelic acid

: 848242-88-6
4-((tert-butoxycarbonyl)amino)heptanedioic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / SOCl₂ / 0 - 20 °C

2: CH₂Cl₂ / 2 h / 20 °C

3: 380 mg / aq. NaOH / methanol / 1 h / 20 °C

With sodium hydroxide; thionyl chloride; In methanol; dichloromethane;
DOI:10.1021/ja0556676

Reference yield: 83.0%

: 848242-88-6
4-((tert-butoxycarbonyl)amino)heptanedioic acid

: 622-33-3
N-benzyloxyamine

: 873843-63-1
N-t-butoxycarbonyl-4-aminopimel-N,N'-(O,O'-dibenzyl)amide

Guidance literature:: 4-((tert-butoxycarbonyl)amino)heptanedioic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 3.5h;

N-benzyloxyamine; In dichloromethane; at 20 ℃;
DOI:10.1021/ja0556676

Reference yield:

: 848242-88-6
4-((tert-butoxycarbonyl)amino)heptanedioic acid

: 1,3,5-benztri-(4-pimel-N,N'-dihydroxylamide)amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N'-carbonyldiimidazole / CH₂Cl₂ / 3.5 h / 20 °C

1.2: 83 percent / CH₂Cl₂ / 20 °C

2.1: CH₂Cl₂ / 0.5 h

3.1: Et₃N / CH₂Cl₂ / 2 h / 20 °C

4.1: 91 percent / H₂ / Pd/C / methanol / 4 h / 836 Torr

With hydrogen; triethylamine; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/ja0556676