1,4-dihydro-2,6-dimethyl-4-(3-methylphenyl)-3,5-pyridinedicarboxylic acid dimethyl ester

Base Information

• Chemical Name: 1,4-dihydro-2,6-dimethyl-4-(3-methylphenyl)-3,5-pyridinedicarboxylic acid dimethyl ester
• CAS No.: 80307-08-0
• Molecular Formula: C18H21NO4
• Molecular Weight: 315.369
• Mol file: 80307-08-0.mol

Synonyms:1,4-Dihydro-2,6-dimethyl-4-(3-methylphenyl)-3,5-pyridinedicarboxylic acid dimethyl ester;2,6-dimethyl-3,5-dicarbomethoxy-4-(3-methylphenyl)-1,4-dihydropyridine;2,6-dimethyl-3,5-bis(methoxycarbonyl)-4-(3-methylphenyl)-1,4-dihydropyridine;3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-methylphenyl)-,dimethyl ester;2,6-dimethyl-3,5-dimethoxycarbonyl-4-(3-methylphenyl)-1,4-dihydropyridine;DDMPC;

Chemical Property of 1,4-dihydro-2,6-dimethyl-4-(3-methylphenyl)-3,5-pyridinedicarboxylic acid dimethyl ester

Chemical Property:

• Vapor Pressure: 6.86E-08mmHg at 25°C
• Boiling Point: 438.5°Cat760mmHg
• Flash Point: 219°C
• PSA: 64.63000
• Density: 1.139g/cm³
• LogP: 2.90460

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-dihydro-2,6-dimethyl-4-(3-methylphenyl)-3,5-pyridinedicarboxylic acid dimethyl ester

There total 2 articles about 1,4-dihydro-2,6-dimethyl-4-(3-methylphenyl)-3,5-pyridinedicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

acetoacetic acid methyl ester (105-45-3) + m-tolyl aldehyde (620-23-5) → 2,6-dimethyl-3,5-bis(methoxycarbonyl)-4-(3-methylphenyl)-1,4-dihydropyridine (80307-08-0)

Guidance literature:

With ammonia; In methanol; Heating;

DOI:10.1021/jm00119a009

Reference yield: 29.0%

m-tolyl aldehyde (620-23-5) + methyl 3-aminocrotonate (14205-39-1) → 2,6-dimethyl-3,5-bis(methoxycarbonyl)-4-(3-methylphenyl)-1,4-dihydropyridine (80307-08-0)

Guidance literature:

In isopropyl alcohol; Heating;

DOI:10.1016/j.tet.2008.04.040

Reference yield: 94.0%

2,6-dimethyl-3,5-bis(methoxycarbonyl)-4-(3-methylphenyl)-1,4-dihydropyridine (80307-08-0) → 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(3-methylphenyl)-pyridine (1037462-12-6)

Guidance literature:

With vanadium(V) oxychloride; In dichloromethane; at 20 ℃; for 1.41667h;

DOI:10.1016/j.tet.2008.08.103

upstream raw materials:

acetoacetic acid methyl ester

m-tolyl aldehyde

methyl 3-aminocrotonate

Downstream raw materials:

1,4-Dihydro-2,6-dimethyl-4-(3-methylphenyl)-3,5-pyridine dicarboxylic acid, 5-methyl-3-(6-phthalimido hex-4-enyl) ester

2,6-dimethyl-3,5-dimethoxycarbonyl-4-(3-methylphenyl)-pyridine