10.1002/adsc.200303241
The research focuses on the development and application of a new family of bidentate phosphine ligands based on the biscarbazole backbone, known as BICAP ligands. These ligands were synthesized and applied in ruthenium- and rhodium-catalyzed asymmetric hydrogenations of methyl acetoacetate and dimethyl itaconate, achieving enantiomeric excesses of 98% and 55%, respectively. The nitrogen atoms in the BICAP ligands allow for the introduction of various substituents, enabling the creation of structurally similar but electronically different ligands to fine-tune the catalytic reactions. Key chemicals involved in the synthesis include diol BICOL, dinonaflate, diphenylphosphine, and various electrophiles such as methyl iodide and trifluoromethanesulfonic anhydride. The study also utilized solvents like acetonitrile, toluene, and phenylsilane, along with reagents like triethylamine, lithium aluminum hydride, and palladium acetate. The research highlights the versatility of the BICAP ligands in optimizing asymmetric catalytic reactions through electronic modifications.
10.1016/j.molstruc.2020.129086
The research focuses on the synthesis, characterization, and theoretical investigation of hydrazine Schiff bases derived from methyl acetoacetate and α-hydroxyacetophenone, along with their anti-proliferative activity against cancer cell lines. The reactants used in the synthesis include 2,4-dinitrophenylhydrazine, methyl acetoacetate, and α-hydroxyacetophenone. The synthesized compounds were characterized using various analytical techniques such as FT-IR, UV–Vis, 1H NMR, mass spectrometry, melting point assessment, and conductivity measurements. Single crystal X-ray diffraction was employed to determine their molecular structures. Theoretical studies were conducted using density functional theory (DFT) calculations to optimize the molecular structures and predict vibrational frequencies and electronic spectra. The anti-cancer effects of the synthesized compounds were evaluated using the MTT assay against K562 (myelogenous leukemia cancer) and MG63 (osteosarcoma cancer) cell lines. The study also involved computational chemistry to analyze the frontier molecular orbitals, which are crucial for understanding the bioactivity of the compounds.
10.1021/ic00134a072
The research focuses on the synthesis and properties of cationic palladium(II) complexes. The key chemicals involved in this research include tetrakis(triphenylphosphine)palladium(0) and tetrakis(triphenylphosphite)palladium(0), which were used as starting materials. The cationic complexes were prepared by reacting these compounds with CPh3X (X = BF4-, PF6-). Other chemicals such as acetylacetone, methyl acetoacetate, and 1,10-phenanthroline were used to further modify the complexes and study their reactions. The resulting complexes were characterized using techniques like 'H NMR and IR spectrometry. The study also explored the oxidation mechanisms and the formation of by-products like hexaphenylethane.
10.1016/S0040-4039(00)82160-7
The study focuses on the synthesis of isotopically labeled pyrroloquinoline quinone (PQQ), a cofactor found in various microbial dehydrogenases, oxidases, and mammalian copper-containing amine oxidases. The researchers adopted and modified existing chemical synthesis schemes to prepare different isotopically labeled PQQ derivatives, such as 3-13C-PQQ, 3-2H-PQQ, and 8-2H-PQQ. The synthesis of 3-13C-PQQ and 3-2H-PQQ involved the Japp-Klingemann hydrazone synthesis, Fischer indolixation, and Doebner-Von Miller type condensation, using starting materials like methoxy-nitro-aniline and methyl-acetoacetate. For 8-2H-PQQ, a Pfitzinger quinoline synthesis was employed, starting from aminoindole and using reagents like isatin, pyruvic acid, and ceric ammonium nitrate. These isotopically labeled PQQ compounds are valuable for studying the biosynthesis, enzymatic redox catalysis, and physiological role of PQQ in different organisms.
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