Cyclopenta[c]pyrrole-2(1H)-carboxylic acid, 5-[[[4-[2-fluoro-4-[[[(phenylacetyl)amino]thioxomethyl]amino]phenoxy]-6- methoxy-7-quinazolinyl]oxy]methyl]hexahydro-, phenylmethyl ester

Base Information

Chemical Name:Cyclopenta[c]pyrrole-2(1H)-carboxylic acid, 5-[[[4-[2-fluoro-4-[[[(phenylacetyl)amino]thioxomethyl]amino]phenoxy]-6- methoxy-7-quinazolinyl]oxy]methyl]hexahydro-, phenylmethyl ester
CAS No.:849217-34-1
Molecular Formula:C40H38FN5O6S
Molecular Weight:735.836
Hs Code.:

Cyclopenta[c]pyrrole-2(1H)-carboxylic acid,
5-[[[4-[2-fluoro-4-[[[(phenylacetyl)amino]thioxomethyl]amino]phenoxy]-6-
methoxy-7-quinazolinyl]oxy]methyl]hexahydro-, phenylmethyl ester

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Chemical Property of Cyclopenta[c]pyrrole-2(1H)-carboxylic acid, 5-[[[4-[2-fluoro-4-[[[(phenylacetyl)amino]thioxomethyl]amino]phenoxy]-6- methoxy-7-quinazolinyl]oxy]methyl]hexahydro-, phenylmethyl ester

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Technology Process of Cyclopenta[c]pyrrole-2(1H)-carboxylic acid, 5-[[[4-[2-fluoro-4-[[[(phenylacetyl)amino]thioxomethyl]amino]phenoxy]-6- methoxy-7-quinazolinyl]oxy]methyl]hexahydro-, phenylmethyl ester

There total 3 articles about Cyclopenta[c]pyrrole-2(1H)-carboxylic acid, 5-[[[4-[2-fluoro-4-[[[(phenylacetyl)amino]thioxomethyl]amino]phenoxy]-6- methoxy-7-quinazolinyl]oxy]methyl]hexahydro-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 849217-32-9
5-[4-(4-amino-2-fluoro-phenoxy)-6-methoxy-quinazolin-7-yloxymethyl]-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid benzyl ester

: 29313-32-4
2-phenylacetyl isothiocyanate

: 849217-34-1
5-{4-[2-fluoro-4-(3-phenylacetyl-thioureido)-phenoxy]-6-methoxy-quinazolin-7-yloxymethyl}-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid benzyl ester

Guidance literature:: In ethanol; toluene; at 20 ℃; for 1 - 2h;

Reference yield:

: 849217-33-0
5-(4-chloro-6-methoxy-quinazolin-7-yloxymethyl)-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid benzyl ester

: 849217-34-1
5-{4-[2-fluoro-4-(3-phenylacetyl-thioureido)-phenoxy]-6-methoxy-quinazolin-7-yloxymethyl}-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 20 °C

1.2: 1 - 2 h / 20 °C

2.1: ethanol; toluene / 1 - 2 h / 20 °C

With sodium hydride; In ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 103-80-0
phenylacetyl chloride

: 849217-34-1
5-{4-[2-fluoro-4-(3-phenylacetyl-thioureido)-phenoxy]-6-methoxy-quinazolin-7-yloxymethyl}-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 2 h / Heating / reflux

2: ethanol; toluene / 1 - 2 h / 20 °C

In ethanol; toluene;