1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylcarbamoyl]-cyclopropanecarboxylic acid

Base Information Edit

Chemical Name:1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylcarbamoyl]-cyclopropanecarboxylic acid
CAS No.:849217-77-2
Molecular Formula:C₂₂H₂₀N₂O₆
Molecular Weight:408.411
Hs Code.:
UNII:QWG9YXZ229
Mol file:849217-77-2.mol

Synonyms:849217-77-2;Cabozantinib metabolite M7;QWG9YXZ229;EXEL-5366;1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylcarbamoyl]-cyclopropanecarboxylic acid;UNII-QWG9YXZ229;Des-4-fluorophenyl cabozantinib;1-(((4-((6,7-Dimethoxy-4-quinolinyl)oxy)phenyl)amino)carbonyl)cyclopropanecarboxylic acid;1-((4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropanecarboxylic acid;1-[[4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]carbamoyl]cyclopropane-1-carboxylic acid;Cyclopropanecarboxylic acid, 1-(((4-((6,7-dimethoxy-4-quinolinyl)oxy)phenyl)amino)carbonyl)-;SCHEMBL372142;HXGYPQKHBCZWKO-UHFFFAOYSA-N;US10273211, Compound 7;BDBM381930;MFCD26389427;1-[[4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl]carbamoyl]cyclopropanecarboxylic Acid;SY272040;CS-0166278;1-((4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylic acid;1-[4-(6,7-Dimethoxyquinolin-4-yloxy)-phenylcarbamoyl]-cyclopropanecarboxylic acid;1-((4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropanecarboxylic acid? (Cabozantinib Impurity)

Suppliers and Price of 1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylcarbamoyl]-cyclopropanecarboxylic acid

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylcarbamoyl]-cyclopropanecarboxylicacid
1g
$ 1680.00

Total 3 raw suppliers

Chemical Property of 1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylcarbamoyl]-cyclopropanecarboxylic acid Edit

Chemical Property:

PSA：106.98000
LogP:3.92060
XLogP3:3.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:7
Exact Mass:408.13213636
Heavy Atom Count:30
Complexity:631

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylcarbamoyl]-cyclopropanecarboxylicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)O
Uses Cabozantinib Des-O-fluoroaniline is a degradation product of Cabozantinib(C051500). Cabozantinib is a small molecule C-Met modulator. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell apoptosis.

Technology Process of 1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylcarbamoyl]-cyclopropanecarboxylic acid

There total 13 articles about 1-[4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylcarbamoyl]-cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.1%

: 40258-99-9
1-(chlorocarbonyl)cyclopropane-1-carboxylic acid

: 190728-25-7
4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline

: 849217-77-2
1-({4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}carbamoyl)cyclopropane-1-carboxylic acid

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield: 68.7%

: 190728-25-7
4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline

: 598-10-7
cyclopropane-1,1-dicarboxylic acid

: 849217-77-2
1-({4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}carbamoyl)cyclopropane-1-carboxylic acid

Guidance literature:: cyclopropane-1,1-dicarboxylic acid; With thionyl chloride; triethylamine; In tetrahydrofuran; at 20 ℃; for 3h;

4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline; In tetrahydrofuran; at 20 ℃; for 16h;