4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine

Base Information

Chemical Name:4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine
CAS No.:190728-25-7
Molecular Formula:C17H16N2O3
Molecular Weight:296.326
Hs Code.:2933499090
European Community (EC) Number:833-600-3
ChEMBL ID:CHEMBL3667501
DSSTox Substance ID:DTXSID40469172
Nikkaji Number:J3.598.033D
Wikidata:Q72468563
Mol file:190728-25-7.mol

Synonyms:190728-25-7;4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline;4-(6,7-DIMETHOXY-QUINOLIN-4-YLOXY)-PHENYLAMINE;4-(6,7-dimethoxyquinolin-4-yl)oxyaniline;4-[(6,7-dimethoxyquinolin-4-yl)oxy]aniline;Benzenamine, 4-[(6,7-dimethoxy-4-quinolinyl)oxy]-;4-(6,7-dimethoxyquinolin-4-yloxy)aniline;4-[(6,7-Dimethoxy-4-quinolyl)oxy]aniline;MFCD19685633;4-(4-Aminophenoxy)-6,7-dimethoxyquinoline;6,7-Dimethoxy-4-(4-aminophenoxy)quinoline;SCHEMBL167396;[4-[(6,7-Dimethoxyquinolin-4-yl)oxy]phenyl]amine;CHEMBL3667501;AMY1790;DTXSID40469172;VXEQRXJATQUJSN-UHFFFAOYSA-N;BDBM153646;BCP10283;AKOS005261203;CCG-332646;SB18182;4-(6,7-Dimethoxy-4-quinolyloxy)aniline;AC-29723;AS-19585;PD121370;SY212142;4-[(6,7Dimethoxy-4-quinolyl)oxy]aniline;CS-0043365;D5070;FT-0701256;4-(6,7-Dimethoxyquinolin-4-yloxy)benzenamine;4-(6,7-dimethoxyquinolin-4-yloxy)phenylamine;4-[(6,7-Dimethoxy-4-quinolyl)oxy-]aniline;6,7-Dimethoxy-4-(4-aminophenyloxy)quinoline;EN300-373698;4-(6,7-Dimethoxy-quinoline-4-yloxy)-phenylamine;A852270;Z2784150670;US8999982, 4-((6,7-dimethoxyquinolin-4- yl)oxy)aniline

Suppliers and Price of 4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TCI Chemical
4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline
1g
$ 473.00

TCI Chemical
4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline
200mg
$ 159.00

Crysdot
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline 95+%
25g
$ 238.00

Chem-Impex
4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline,≥98%(HPLC) ≥98%(HPLC)
1G
$ 540.80

Chemenu
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline 95%
25g
$ 224.00

Ambeed
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline 97%
25g
$ 232.00

Ambeed
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline 97%
1g
$ 18.00

Ambeed
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline 97%
250mg
$ 11.00

Ambeed
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline 97%
10g
$ 100.00

Ambeed
4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline 97%
5g
$ 54.00

Total 101 raw suppliers

Chemical Property of 4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine

Chemical Property:

Melting Point:211.0 to 215.0 °C
Boiling Point:481.8±45.0 °C(Predicted)
PKA:6.79±0.30(Predicted)
PSA：66.60000
Density:1.246±0.06 g/cm3 (20 oC 760 Torr)
LogP:4.20770
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
XLogP3:3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:296.11609238
Heavy Atom Count:22
Complexity:347

Purity/Quality:

99%, ^*data from raw suppliers

4-[(6,7-Dimethoxyquinolin-4-yl)oxy]aniline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)N
Uses 4-(6,7-Dimethoxy-Quinolin-4-Yloxy)-Phenylamine is used in preparation of Cabozantinib Defluorination impurity.

Technology Process of 4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine

There total 23 articles about 4-(6,7-Dimethoxy-quinolin-4-yloxy)-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 190728-24-6
6,7?dimethoxy?4?(4?nitrophenoxy)quinoline

: 190728-25-7
4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline

Guidance literature:: With ammonium chloride; zinc; In tetrahydrofuran; methanol; water; for 2h; Heating / reflux;

Reference yield: 97.0%

: 6,7-dimethoxy-4-(4-nitro-phenoxy)-quinoline

: 190728-25-7
4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline

Guidance literature:: With formic acid; palladium 10% on activated carbon; potassium formate; In tetrahydrofuran; water; at 60 ℃; for 15h; Large scale;