1H-Pyrrole-3-carboxamide, 2,5-dihydro-N-(2-((hydroxyphenylacetyl)amino)ethyl)-2,2,5,5-tetramethyl-

Base Information

Chemical Name:1H-Pyrrole-3-carboxamide, 2,5-dihydro-N-(2-((hydroxyphenylacetyl)amino)ethyl)-2,2,5,5-tetramethyl-
CAS No.:93823-61-1
Molecular Formula:C₁₉H₂₇N₃O₃
Molecular Weight:345.442
Hs Code.:
ChEMBL ID:CHEMBL2079618
DSSTox Substance ID:DTXSID40917724

Synonyms:BRN 5993124;1H-Pyrrole-3-carboxamide, 2,5-dihydro-N-(2-((hydroxyphenylacetyl)amino)ethyl)-2,2,5,5-tetramethyl-;93823-61-1;CHEMBL2079618;DTXSID40917724;N-{2-[(1,2-Dihydroxy-2-phenylethylidene)amino]ethyl}-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrole-3-carboximidic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Pyrrole-3-carboxamide, 2,5-dihydro-N-(2-((hydroxyphenylacetyl)amino)ethyl)-2,2,5,5-tetramethyl-

Chemical Property:

XLogP3:0.6
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:345.20524173
Heavy Atom Count:25
Complexity:534

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(C=C(C(N1)(C)C)C(=O)NCCNC(=O)C(C2=CC=CC=C2)O)C

Technology Process of 1H-Pyrrole-3-carboxamide, 2,5-dihydro-N-(2-((hydroxyphenylacetyl)amino)ethyl)-2,2,5,5-tetramethyl-

There total 3 articles about 1H-Pyrrole-3-carboxamide, 2,5-dihydro-N-(2-((hydroxyphenylacetyl)amino)ethyl)-2,2,5,5-tetramethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 93799-43-0
mandelic acid N-hydroxysuccinimido ester

: 93799-56-5
2,2,5,5-Tetramethyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid (2-amino-ethyl)-amide

: 93823-61-1
2,2,5,5-Tetramethyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid [2-(2-hydroxy-2-phenyl-acetylamino)-ethyl]-amide

Guidance literature:: In chloroform; for 4h; Heating;
DOI:10.1021/jm00157a005

Reference yield:

: 611-71-2,611-72-3,17199-29-0,90-64-2
MANDELIC ACID

: 93823-61-1
2,2,5,5-Tetramethyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid [2-(2-hydroxy-2-phenyl-acetylamino)-ethyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / N,N'-dicyclohexylcarbodiimide / ethyl acetate

2: 63 percent / CHCl₃ / 4 h / Heating

With dicyclohexyl-carbodiimide; In chloroform; ethyl acetate;
DOI:10.1021/jm00157a005

Reference yield:

: 19971-12-1
3,5-Dibromo-4-oxo-2,2,6,6-tetramethylpiperidine Hydrobromide

: 93823-61-1
2,2,5,5-Tetramethyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid [2-(2-hydroxy-2-phenyl-acetylamino)-ethyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / H₂O / 3 h / 25 °C

2: 63 percent / CHCl₃ / 4 h / Heating

In chloroform; water;
DOI:10.1021/jm00157a005