Technology Process of 2(5H)-Furanone,3,4-bis(phenylmethyl)-5- (phenylmethylene)-,(5Z)-
There total 7 articles about 2(5H)-Furanone,3,4-bis(phenylmethyl)-5- (phenylmethylene)-,(5Z)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-<(phenylmethyl)sulfonyl>pyridine; 2,3-dibenzylbut-2-en-dioic anhydride;
With
boron trifluoride diethyl etherate; lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 ℃;
for 0.75h;
Inert atmosphere;
With
acetic acid;
In
tetrahydrofuran;
at -78 - 20 ℃;
Inert atmosphere;
In
tetrahydrofuran; toluene;
at 140 ℃;
for 2h;
Sealed tube;
Microwave irradiation;
DOI:10.1021/acs.orglett.6b02160
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 100 percent / Br2 / CCl4 / 6 h / 20 °C
2.1: 100 percent / Ac2O / 1.5 h / Heating
3.1: Mg / diethyl ether / 4.5 h / 20 °C
3.2: 45 percent / CuI / diethyl ether; hexamethylphosphoric acid triamide / -5 - 20 °C
4.1: 91 percent / NaBH4 / tetrahydrofuran / 2 h / 0 °C
5.1: 77 percent / piperidine / methanol / 15 h / 20 °C
With
piperidine; sodium tetrahydroborate; bromine; acetic anhydride; magnesium;
In
tetrahydrofuran; methanol; tetrachloromethane; diethyl ether;
5.1: Knoevenagel condensation;
DOI:10.1016/j.tet.2005.03.065
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: Mg / diethyl ether / 4.5 h / 20 °C
1.2: 45 percent / CuI / diethyl ether; hexamethylphosphoric acid triamide / -5 - 20 °C
2.1: 91 percent / NaBH4 / tetrahydrofuran / 2 h / 0 °C
3.1: 77 percent / piperidine / methanol / 15 h / 20 °C
With
piperidine; sodium tetrahydroborate; magnesium;
In
tetrahydrofuran; methanol; diethyl ether;
3.1: Knoevenagel condensation;
DOI:10.1016/j.tet.2005.03.065
