71481-05-5Relevant academic research and scientific papers
Synthesis of maculalactone A and derivatives for environmental fate tracking studies
Bader, Samuel L.,Luescher, Michael U.,Gademann, Karl
supporting information, p. 199 - 206 (2015/02/19)
Maculalactone A (1) constitutes a promising antifouling agent, inhibiting the formation of biofilms in marine and freshwater systems. In this study, we developed a new route, based on a late-stage formation of the butenolide core, leading to the total synthesis of maculalactone A (three steps, overall yield of 45%) and delivering material on a gram scale. In addition, analogues of the title compound were assayed concerning their biological activity, utilizing Artemia franciscana and Thamnocephalus platyurus. The most active analogue was functionalized with a rhodamine B fluorophore and was utilized in an in vivo staining experiment in Artemia salina. Two different tissues were found to accumulate this maculalactone A derivative. This journal is
Regioselective monoalkylation of dimethyl alkylidenesuccinates: Simple approach to dialkyl-substituted maleic anhydrides including chaetomellic acid A
Kshirsagar, Umesh A.,Argade, Narshinha P.
, p. 1804 - 1808 (2011/07/29)
Natural and nonnatural dialkylmaleic anhydrides were readily prepared from dimethyl alkylidenesuccinates by sodium hexamethyldisilazide-induced selective monoalkylation followed by base-catalyzed hydrolysis. Georg Thieme Verlag Stuttgart - New York.
A facile synthesis of alkyl substituted maleic anhydrides: radical approach
Messorosh, Artyom V.,Trukhin, Alexey V.,Eliseenkov, Evgenii V.
, p. 10849 - 10852 (2008/12/23)
Synthetic background for the preparation of alkyl substituted maleic anhydrides and maleimides based on radical alkylation of 2,3-dichloromaleic anhydride (maleimide) by hydrocarbons was developed. The best conditions for the selective synthesis of 2-alkyl-3-chloro- and unsymmetrically substituted dialkylmaleic anhydrides were elaborated.
Metallo-beta-lactamase inhibitors
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Page/Page column 20, (2010/11/30)
A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.
Synthesis of naturally occurring bioactive butyrolactones: Maculalactones A-C and nostoclide I
Kar, Anirban,Gogoi, Sanjib,Argade, Narshinha P.
, p. 5297 - 5302 (2007/10/03)
Starting from citraconic anhydride (13), a simple multistep (9-10 steps) synthesis of naturally occurring butyrolactones maculalactone A (3), maculalactone B (1), maculalactone C (2) and nostoclide I (4) have been described with good overall yields via di
Total synthesis of (±) maculalactone A, maculalactone B and maculalactone C and the determination of the absolute configuration of natural (+) maculalactone A by asymmetric synthesis
Brown, Geoffrey D.,Wong, Ho-Fai
, p. 5439 - 5451 (2007/10/03)
Maculalactones A, B and C from the marine cyanobacterium Kyrtuthrix maculans are amongst the only compounds based on the tribenzylbutyrolactone skeleton known in nature and (+) maculalactone A from the natural source possesses significant biological activ
