Technology Process of Benzenesulfonamide,
3-[[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-phenyl-1H-imidazo[4,5-c]pyridin-
6-yl]oxy]-N-[2-(4-morpholinyl)ethyl]-
There total 11 articles about Benzenesulfonamide,
3-[[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-phenyl-1H-imidazo[4,5-c]pyridin-
6-yl]oxy]-N-[2-(4-morpholinyl)ethyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: trichlorophosphate / toluene / 16 h / 0 - 110 °C / Heating / reflux
2: tert.-butylhydroperoxide; potassium tert-butylate; ammonia / tetrahydrofuran; decane / 3.08 h / -78 - 0 °C
3: trichlorophosphate / toluene / 60 °C / Heating / reflux
4: triethylamine / tetrahydrofuran / 18 h / 20 °C
5: sodium hydride / N,N-dimethyl-formamide / 60 °C
6: hydrogen / 5%-palladium/activated carbon / methanol
7: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C
8: acetic acid / 5 h / 110 °C
9: hydrogenchloride; sodium nitrite / methanol; water / 0.5 h / 20 °C
10: hydroxylamine; triethylamine / 1,4-dioxane; water / 110 °C
With
hydrogenchloride; tert.-butylhydroperoxide; potassium tert-butylate; ammonia; hydrogen; hydroxylamine; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite; trichlorophosphate;
5%-palladium/activated carbon;
In
tetrahydrofuran; 1,4-dioxane; methanol; decane; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
With
hydroxylamine; triethylamine;
In
1,4-dioxane; water;
at 110 ℃;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: trichlorophosphate / toluene / 60 °C / Heating / reflux
2: triethylamine / tetrahydrofuran / 18 h / 20 °C
3: sodium hydride / N,N-dimethyl-formamide / 60 °C
4: hydrogen / 5%-palladium/activated carbon / methanol
5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C
6: acetic acid / 5 h / 110 °C
7: hydrogenchloride; sodium nitrite / methanol; water / 0.5 h / 20 °C
8: hydroxylamine; triethylamine / 1,4-dioxane; water / 110 °C
With
hydrogenchloride; hydrogen; hydroxylamine; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite; trichlorophosphate;
5%-palladium/activated carbon;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene;
