3-FLUORO-5-METHOXY-PHENOL

Base Information

• Chemical Name: 3-FLUORO-5-METHOXY-PHENOL
• CAS No.: 850793-25-8
• Molecular Formula: C7H7FO2
• Molecular Weight: 142.13
• Hs Code.: 2909500000
• Mol file: 850793-25-8.mol

Synonyms:3-FLUORO-5-HYDROXYANISOLE;CL8490;Phenol,3-fluoro-5-methoxy;3-Fluoro-5-methoxy-phenol;

Chemical Property of 3-FLUORO-5-METHOXY-PHENOL

Chemical Property:

• Boiling Point: 222.0±20.0 °C(Predicted)
• PKA: 8.59±0.10(Predicted)
• PSA: 29.46000
• Density: 1.224±0.06 g/cm3(Predicted)
• LogP: 1.53990
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Fluoro-5-methoxyphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-FLUORO-5-METHOXY-PHENOL

There total 3 articles about 3-FLUORO-5-METHOXY-PHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-chloro-3-fluoro-5-methoxybenzene (202925-08-4) → 3-fluoro-5-methoxyphenol (850793-25-8)

Guidance literature:

With copper acetylacetonate; N¹-(4-hydroxy-2,6-dimethylphenyl)-N²-(4-hydroxy-3,5-dimethylphenyl)oxalamide; water; In water; dimethyl sulfoxide; at 130 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1021/jacs.6b08114

Reference yield: 75.0%

3,5-dimethoxyfluorobenzene (52189-63-6) → 3-fluoro-5-methoxyphenol (850793-25-8)

Guidance literature:

With boron tribromide; In dichloromethane; for 7h; Reflux;

Reference yield:

3-fluoro-5-methoxyphenylboronic acid (609807-25-2) → 3-fluoro-5-methoxyphenol (850793-25-8)

Guidance literature:

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; water; at 20 ℃; Cooling with ice;

upstream raw materials:

3,5-dimethoxyfluorobenzene

3-fluoro-5-methoxyphenylboronic acid

1-chloro-3-fluoro-5-methoxybenzene

Downstream raw materials:

tert-butyl (3-endo)-3-(3-fluoro-5-methoxyphenoxy)-8-azabicyclo[3.2.1]octane-8-carboxylate

Refernces

• 1、 Xia, Shanghua,Gan, Lu,Wang, Kailiang,Li, Zheng,Ma, Dawei. "Copper-Catalyzed Hydroxylation of (Hetero)aryl Halides under Mild Conditions". supporting information. p. 13493 - 13496. Retrieved 2016/10/31.
• 2、 -. "8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXAMIDE DERIVATIVE". Page/Page column 57. . Retrieved 2012/09/11.