52189-63-6

Usage

Uses

Used in Pharmaceutical Industry:
1,3-Dimethoxy-5-fluorobenzene is used as a key intermediate for the synthesis of 5-fluoro-benzene-1,3-diol, which is an important compound in the development of pharmaceuticals. The synthesis is facilitated by reagents such as tetrabutylammonium iodide and boron trichloride, which enable the conversion of the starting material into the desired product.
Additionally, due to its unique structure, 1,3-Dimethoxy-5-fluorobenzene may have potential applications in other industries, such as in the development of agrochemicals, dyes, or materials science, where its specific properties can be exploited for various purposes.

InChI:InChI=1/C8H9FO2/c1-10-7-3-6(9)4-8(5-7)11-2/h3-5H,1-2H3

Upstream product

• 20469-65-2 1-bromo-3,5-dimethoxybenzene 
• 54132-76-2 3,5-dimethoxyphenyl isocyanate 
• 10272-07-8 3.5-dimethoxyaniline 
• 17213-58-0 3,5-dimethoxybenzamide 
• 99-10-5 3,5-Dihydroxybenzoic acid 
• 17275-82-0 ethyl 3,5-dimethoxybenzoate 
• 72470-95-2 3,5-dimethoxybenzenediazonium tetrafluoroborate 
• 51707-38-1 3,5-dimethoxy-benzoic acid hydrazide 
• 75996-26-8 azido(3,5-dimethoxyphenyl)methanone 
• 17213-57-9 3,5-dimethoxybenzoyl chloride 
• 1132-21-4 3,5-dimethoxybenzoic acid 

Downstream Products

• 75996-28-0 2-ethyl-4,6-dimethoxy-benzoic acid 
• 52189-66-9 2,4-dimethoxy-6-pentadecylbenzoic acid 
• 23032-48-6 1,3-dimethoxy-5-pentadecylbenzene 
• 52189-64-7 2,4-dimethoxy-6-propylbenzoic acid 
• 214492-73-6 2-fluoro-4,6-dimethoxybenzaldehyde 
• 139549-11-4 4-fluoro-2,6-dimethoxybenzaldehyde 
• 102739-73-1 4-(5-(1,3-dimethoxy)phenyl)morpholine 
• 206860-47-1 2-bromo-1-fluoro-3,5-dimethoxybenzene 
• 1569070-66-1 C₂₈H₂₅FN₄O₄ 
• 1569071-04-0 C₁₇H₂₅FN₂O₂Si 
• 1569070-26-3 C₂₈H₂₄FN₃O₅*ClH 
• 1569070-23-0 C₂₈H₂₄FN₃O₄S*ClH 

Relevant academic research and scientific papers

TRISUBSTITUTED BORON-CONTAINING MOLECULES

This invention largely relates to 3,4,6-trisubstituted benzoxaborole compounds, and their use for treating bacterial infections.

Efficient synthesis of aryl fluorides

Chemical Equation Presented Creating C-F bonds: A novel electrophilic fluorination of aryl and heteroaryl Crignard reagents has been discovered and was used for the efficient synthesis of various aryl fluoride derivatives (see picture; THF = tetrahydrofuran).

Preparation process of fluorine substituted aromatic compound

A preparation process of a fluorine substituted aromatic compound comprising reacting an alkali metal or alkali earth metal salt of an aromatic compound having a hydroxy group with an organic fluorinating agent is disclosed. As a representative fluorinating agent, a bis-dialkylamino-difluoromethane compound, for example, 2,2′-difluoro-1,3-dimethylimidazolidine, is exemplified. According to the process, an industrially useful fluorinated aromatic compound, for example, a fluorobenzene, a fluorine substituted benzophenone, a fluorine substituted diarylsulfone can be prepared with ease in economy without specific equipment.

Long-chain Phenols. Part 16. A Novel Synthesis of Homologous Orsellinic Acids and their Methyl Ethers

By the novel reaction of 3,5-dimethoxyfluorobenzene with n-alkyl-lithium compounds, followed by carbonation, homologous orsellinic acid dimethyl ethers (6-alkyl-2,4-dimethoxybenzoic acids) have been obtained.The reactions proceeded best with the homologues of methyl-lithium.These reactions are considered to occur by way of 3,5-dimethoxybenzyne. 2,4-Dimethoxyfluorobenzene did not form an aryne but gave 3-fluoro-2,6-dimethoxybenzoic acid instead.Decomposition with water of alkyl-lithium reaction mixtures from 3,5-dimethoxyfluorobenzene yielded 5-n-alkylresorcinol dimethyl ethers.Demethylaton of 6-alkyl-2,4-dimethoxybenzoic acids with boron trichloride proceeded partially and selectively to give the 6-alkyl-2-hydroxy-4-methoxybenzoic acids, and completely with aluminium chloride to give the homologous orsellinic acids.Boron tribromide was less effective, but readily gave the 5-alkyl resorcinols from the corresponding dimethyl ethers.