Propanoic acid, 3-oxo-3-(3-pyridinylamino)-, phenylmethyl ester

Base Information

• Chemical Name: Propanoic acid, 3-oxo-3-(3-pyridinylamino)-, phenylmethyl ester
• CAS No.: 851680-49-4
• Molecular Formula: C15H14N2O3
• Molecular Weight: 270.288
• Mol file: 851680-49-4.mol

Synonyms:

Chemical Property of Propanoic acid, 3-oxo-3-(3-pyridinylamino)-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanoic acid, 3-oxo-3-(3-pyridinylamino)-, phenylmethyl ester

There total 1 articles about Propanoic acid, 3-oxo-3-(3-pyridinylamino)-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.5%

pyridin-3-ylamine (462-08-8) + Malonic acid monobenzyl ester acid chloride (69479-87-4) → N-Pyridin-3-yl-malonamic acid benzyl ester (851680-49-4)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

N-Pyridin-3-yl-malonamic acid benzyl ester (851680-49-4) → N-{2-[(S)-3-hydroxy-pyrrolidin-1-yl]-(S)-1-phenyl-ethyl}-N-methyl-N'-pyridin-3-yl-malonamide

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / methanol

2: 2-chloro-1-methylpyridinium iodide; Et₃N / CH₂Cl₂

With 2-chloro-1-methyl-pyridinium iodide; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2007.01.053

upstream raw materials:

pyridin-3-ylamine

Malonic acid monobenzyl ester acid chloride