N-(2,4-diMethoxybenzyl)thiazol-2-aMine

Base Information

• Chemical Name: N-(2,4-diMethoxybenzyl)thiazol-2-aMine
• CAS No.: 853994-53-3
• Molecular Formula: C12H14N2O2S
• Molecular Weight: 250.321
• Mol file: 853994-53-3.mol

Synonyms:N-(2,4-dimethoxybenzyl)-1,3-thiazol-2-amine;(2,4-Dimethoxy-benzyl)-thiazol-2-yl-amine;(2,4-dimethoxybenzyl)-thiazol-2-yl-amine;N-(2,4-Dimethoxybenzyl)-1,3-thiazol-2-yl-amine;N-(2,4-dimethoxybenzyl)thiazol-2-amine;

Chemical Property of N-(2,4-diMethoxybenzyl)thiazol-2-aMine

Chemical Property:

• PSA: 71.62000
• LogP: 2.84540

Purity/Quality:

97% ^*data from raw suppliers

N-(2,4-Dimethoxybenzyl)thiazol-2-amine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2,4-diMethoxybenzyl)thiazol-2-aMine

There total 4 articles about N-(2,4-diMethoxybenzyl)thiazol-2-aMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-thiazolylamine (96-50-4) + 2,4-Dimethoxybenzaldehyde (613-45-6) → N-(2,4-dimethoxybenzyl)-N-(1,3-thiazol-2-yl)amine (853994-53-3)

Guidance literature:

2-thiazolylamine; 2,4-Dimethoxybenzaldehyde; In toluene; at 105 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In toluene; at 35 ℃; for 0.5h;

Reference yield:

[1-(2,4-Dimethoxy-phenyl)-meth-(E)-ylidene]-thiazol-2-yl-amine → N-(2,4-dimethoxybenzyl)-N-(1,3-thiazol-2-yl)amine (853994-53-3)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; for 6h;

DOI:10.1016/j.tetlet.2005.02.155

Reference yield:

2,4-Dimethoxybenzaldehyde (613-45-6) → N-(2,4-dimethoxybenzyl)-N-(1,3-thiazol-2-yl)amine (853994-53-3)

Guidance literature:

Multi-step reaction with 2 steps

1: TiCl(OiPr)3 / CH₂Cl₂ / 0.08 h

2: 181 mg / NaBH(OAc)3; AcOH / CH₂Cl₂ / 6 h

With triisopropoxytitanium(IV) chloride; sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane;

DOI:10.1016/j.tetlet.2005.02.155

upstream raw materials:

2,4-Dimethoxybenzaldehyde

2-thiazolylamine

Downstream raw materials:

N-(2,4-dimethoxybenzyl)-5-iodo-N-(thiazol-2-yl)pyridine-2-sulfonamide

methyl 4-{[(2,4-dimethoxybenzyl)(1,3-thiazol-2-yl)amino]sulfonyl}-2-fluorobenzoate

N-(2,4-dimethoxybenzyl)-2-oxo-N-(1,3-thiazol-2-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide

N-(2,4-dimethoxybenzyl)-5-fluoro-2-oxo-N-(1,3-thiazol-2-yl)-2,3-dihydrobenzo[d]oxazole-6-sulfonamide