3-cyano-N-(2,4-dimethoxybenzyl)-4-fluoro-N-(thiazol-2-yl)benzene sulfonamide

Base Information

Chemical Name:3-cyano-N-(2,4-dimethoxybenzyl)-4-fluoro-N-(thiazol-2-yl)benzene sulfonamide
CAS No.:1354787-26-0
Molecular Formula:C₁₉H₁₆FN₃O₄S₂
Molecular Weight:433.484
Hs Code.:

Synonyms:3-cyano-N-(2,4-dimethoxybenzyl)-4-fluoro-N-(thiazol-2-yl)benzene sulfonamide

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Chemical Property of 3-cyano-N-(2,4-dimethoxybenzyl)-4-fluoro-N-(thiazol-2-yl)benzene sulfonamide

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Technology Process of 3-cyano-N-(2,4-dimethoxybenzyl)-4-fluoro-N-(thiazol-2-yl)benzene sulfonamide

There total 2 articles about 3-cyano-N-(2,4-dimethoxybenzyl)-4-fluoro-N-(thiazol-2-yl)benzene sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 853994-53-3
N-(2,4-dimethoxybenzyl)-N-(1,3-thiazol-2-yl)amine

: 351003-23-1
3-cyano-4-fluorobenzene-1-sulfonyl chloride

: 1354787-26-0
3-cyano-N-(2,4-dimethoxybenzyl)-4-fluoro-N-(thiazol-2-yl)benzene sulfonamide

Guidance literature:: N-(2,4-dimethoxybenzyl)-N-(1,3-thiazol-2-yl)amine; With lithium hexamethyldisilazane; In tetrahydrofuran; at -50 - 20 ℃; for 0.5h;

3-cyano-4-fluorobenzene-1-sulfonyl chloride; In tetrahydrofuran; at -78 ℃; for 0.5h;

Reference yield:

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 1354787-26-0
3-cyano-N-(2,4-dimethoxybenzyl)-4-fluoro-N-(thiazol-2-yl)benzene sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: piperidine / 1,1-dichloroethane / 18 h / Reflux; Molecular sieve

1.2: 2 h / Reflux

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -50 - 20 °C

2.2: 0.5 h / -78 °C

With piperidine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,1-dichloroethane;

Reference yield: 87.0%

: 1354787-25-9
4-bromo-2-(1-methyl-1H-pyrazol-5-yl)phenol

: 1354787-26-0
3-cyano-N-(2,4-dimethoxybenzyl)-4-fluoro-N-(thiazol-2-yl)benzene sulfonamide

: 1354787-24-8
4-[4-bromo-2-(2-methyl-2H-pyrazol-3-yl)-phenoxy]-3-cyano-N-(2,4-dimethoxy-benzyl)-N-thiazol-2-yl-benzenesulfonamide

Guidance literature:: 4-bromo-2-(1-methyl-1H-pyrazol-5-yl)phenol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.5h;

3-cyano-N-(2,4-dimethoxybenzyl)-4-fluoro-N-(thiazol-2-yl)benzene sulfonamide; In N,N-dimethyl-formamide; mineral oil; for 3h;