Phenyl[4-phenyl-8-(trifluoromethyl)quinolin-3-yl]methanone

Base Information

Chemical Name:Phenyl[4-phenyl-8-(trifluoromethyl)quinolin-3-yl]methanone
CAS No.:854765-40-5
Molecular Formula:C23H14F3NO
Molecular Weight:377.365
Hs Code.:
ChEMBL ID:CHEMBL425099
DSSTox Substance ID:DTXSID40463579

Synonyms:Phenyl[4-phenyl-8-(trifluoromethyl)quinolin-3-yl]methanone;Quinoline 4;854765-40-5;Phenyl-[4-phenyl-8-(trifluoromethyl)quinolin-3-yl]methanone;CHEMBL425099;SCHEMBL1124681;BDBM19994;DTXSID40463579;3-benzoyl-4-phenyl-8-(trifluoromethyl)quinoline

Suppliers and Price of Phenyl[4-phenyl-8-(trifluoromethyl)quinolin-3-yl]methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Phenyl[4-phenyl-8-(trifluoromethyl)quinolin-3-yl]methanone

Chemical Property:

XLogP3:6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:377.10274856
Heavy Atom Count:28
Complexity:537

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=C3C=CC=C(C3=NC=C2C(=O)C4=CC=CC=C4)C(F)(F)F

Technology Process of Phenyl[4-phenyl-8-(trifluoromethyl)quinolin-3-yl]methanone

There total 5 articles about Phenyl[4-phenyl-8-(trifluoromethyl)quinolin-3-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 4-phenyl-8-(trifluoromethyl)quinoline-3-carbaldehyde

: 98-80-6
phenylboronic acid

: 854765-40-5
phenyl[4-phenyl(8-trifluoromethyl)quinolin-3-yl]methanone

Guidance literature:: 4-phenyl-8-(trifluoromethyl)quinoline-3-carbaldehyde; phenylboronic acid; With 1-(2,6-diisopropylphenyl)-3-(2-(phenylthio)phenyl)-4,5-dihydroimidazolinium chloride; bis(η3-allyl-μ-chloropalladium(II)); caesium carbonate; In 1,4-dioxane; at 100 ℃; for 1h; Inert atmosphere;

With ortho-methylphenyl iodide; In 1,4-dioxane; at 100 ℃; for 15h; Inert atmosphere;
DOI:10.1002/ejoc.201300269

Reference yield:

: 854777-89-2
[4-chloro-8-(trifluoromethyl)quinolin-3-yl](phenyl)methanone

: 98-80-6
phenylboronic acid

: 854765-40-5
phenyl[4-phenyl(8-trifluoromethyl)quinolin-3-yl]methanone

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 90 ℃; for 4h;

Reference yield:

: 4-chloro-8-(trifluoromethyl)quinoline-3-carbaldehyde

: 854765-40-5
phenyl[4-phenyl(8-trifluoromethyl)quinolin-3-yl]methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 20 h / Reflux

2.1: bis(η3-allyl-μ-chloropalladium(II)); 1-(2,6-diisopropylphenyl)-3-(2-(phenylthio)phenyl)-4,5-dihydroimidazolinium chloride; caesium carbonate / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

2.2: 15 h / 100 °C / Inert atmosphere

With 1-(2,6-diisopropylphenyl)-3-(2-(phenylthio)phenyl)-4,5-dihydroimidazolinium chloride; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(η3-allyl-μ-chloropalladium(II)); caesium carbonate; In 1,4-dioxane;
DOI:10.1002/ejoc.201300269