6-(hydroxymethyl)-4-(3-methoxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

Base Information Edit

Chemical Name:6-(hydroxymethyl)-4-(3-methoxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
CAS No.:857272-03-8
Molecular Formula:C13H17NO4
Molecular Weight:251.27800
Hs Code.:
Mol file:857272-03-8.mol

Synonyms:6-HYDROXYMETHYL-4-(3-METHOXYPROPYL)-4H-BENZO[1,4]OXAZIN-3-ONE;

Suppliers and Price of 6-(hydroxymethyl)-4-(3-methoxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 4 raw suppliers

Chemical Property of 6-(hydroxymethyl)-4-(3-methoxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-one Edit

Chemical Property:

PSA：59.00000
Density:1.221
LogP:1.00580

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6-(hydroxymethyl)-4-(3-methoxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

There total 2 articles about 6-(hydroxymethyl)-4-(3-methoxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 615568-17-7
6-hydroxymethyl-4H-benzo[1,4]oxazin-3-one

: 36215-07-3
1-Chloro-3-methoxypropane

: 857272-03-8
6-hydroxymethyl-4-(3-methoxy-propyl)-4H-benzo[1,4]oxazin-3-one

Guidance literature:: 6-hydroxymethyl-4H-benzo[1,4]oxazin-3-one; 1-Chloro-3-methoxypropane; With potassium fluoride on basic alumina; potassium iodide; In acetonitrile; for 72h; Heating / reflux;

With hydrogenchloride; water;

Reference yield:

: 604756-32-3,202195-67-3
methyl 3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate

: 857272-03-8
6-hydroxymethyl-4-(3-methoxy-propyl)-4H-benzo[1,4]oxazin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2 h / -40 - -20 °C

2: potassium fluoride; potassium iodide / acetonitrile / 72 h / Heating / reflux

With potassium fluoride; diisobutylaluminium hydride; potassium iodide; In tetrahydrofuran; toluene; acetonitrile;

Reference yield:

: 857272-03-8
6-hydroxymethyl-4-(3-methoxy-propyl)-4H-benzo[1,4]oxazin-3-one

: 873946-54-4
3-[4-{4-[1-(3-fluoro-phenyl)pyrrolidin-3-yloxy]-phenyl}-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulfonyl)-piperidin-3-yloxy]-propionitrile

Guidance literature:: Multi-step reaction with 7 steps

1: thionyl chloride / pyridine; dichloromethane / 1 h / 0 - 20 °C

2: sodium hydride / N,N-dimethyl-formamide / 19 h / -10 - 20 °C

3: borane-THF / tetrahydrofuran / 1 - 3 h / 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 - 2 h / 20 °C

5: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 2 - 20 h / 15 - 20 °C

6: sodium carbonate / water; ethyl acetate / 1 h / 0 °C

7: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 72 h / 20 - 50 °C

With thionyl chloride; borane-THF; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium 10% on activated carbon; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;