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6-(hydroxymethyl)-4-(3-methoxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

Base Information Edit
  • Chemical Name:6-(hydroxymethyl)-4-(3-methoxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
  • CAS No.:857272-03-8
  • Molecular Formula:C13H17NO4
  • Molecular Weight:251.27800
  • Hs Code.:
  • Mol file:857272-03-8.mol
6-(hydroxymethyl)-4-(3-methoxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

Synonyms:6-HYDROXYMETHYL-4-(3-METHOXYPROPYL)-4H-BENZO[1,4]OXAZIN-3-ONE;

Suppliers and Price of 6-(hydroxymethyl)-4-(3-methoxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
Total 4 raw suppliers
Chemical Property of 6-(hydroxymethyl)-4-(3-methoxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-one Edit
Chemical Property:
  • PSA:59.00000 
  • Density:1.221 
  • LogP:1.00580 
Purity/Quality:

99% *data from raw suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
Technology Process of 6-(hydroxymethyl)-4-(3-methoxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-one

There total 2 articles about 6-(hydroxymethyl)-4-(3-methoxypropyl)-2H-benzo[b][1,4]oxazin-3(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
6-hydroxymethyl-4H-benzo[1,4]oxazin-3-one; 1-Chloro-3-methoxypropane; With potassium fluoride on basic alumina; potassium iodide; In acetonitrile; for 72h; Heating / reflux;
With hydrogenchloride; water;
Guidance literature:
Multi-step reaction with 2 steps
1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2 h / -40 - -20 °C
2: potassium fluoride; potassium iodide / acetonitrile / 72 h / Heating / reflux
With potassium fluoride; diisobutylaluminium hydride; potassium iodide; In tetrahydrofuran; toluene; acetonitrile;
Guidance literature:
Multi-step reaction with 7 steps
1: thionyl chloride / pyridine; dichloromethane / 1 h / 0 - 20 °C
2: sodium hydride / N,N-dimethyl-formamide / 19 h / -10 - 20 °C
3: borane-THF / tetrahydrofuran / 1 - 3 h / 20 °C
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 - 2 h / 20 °C
5: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 2 - 20 h / 15 - 20 °C
6: sodium carbonate / water; ethyl acetate / 1 h / 0 °C
7: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 72 h / 20 - 50 °C
With thionyl chloride; borane-THF; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium 10% on activated carbon; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
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