N-(3-aminophenyl)-2-phenylacetamide

Base Information

• Chemical Name: N-(3-aminophenyl)-2-phenylacetamide
• CAS No.: 85856-32-2
• Molecular Formula: C14H14N2O
• Molecular Weight: 226.278
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID50429186
• Nikkaji Number: J1.589.533K
• ChEMBL ID: CHEMBL441539
• Mol file: 85856-32-2.mol

Synonyms:N-(3-aminophenyl)-2-phenylacetamide;85856-32-2;CHEMBL441539;SCHEMBL3454266;N-(3-aminophenyl)phenylacetamide;DTXSID50429186;DAXUGYVWKQUGTB-UHFFFAOYSA-N;N-(3-Aminophenyl)benzeneacetamide;N-(3-aminophenyl) phenylacetamide;BBL011984;MFCD01806275;STK360020;AKOS000160945;VS-03144;BB 0256455;FT-0718487;MLS-0315652.0001;AN-652/41610221

Chemical Property of N-(3-aminophenyl)-2-phenylacetamide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 489.059oC at 760 mmHg
• PKA: 14.70±0.70(Predicted)
• Flash Point: 249.574oC
• PSA: 55.12000
• Density: 1.22g/cm3
• LogP: 3.10420
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 226.110613074
• Heavy Atom Count: 17
• Complexity: 249

Purity/Quality:

98%min ^*data from raw suppliers

N-(3-Aminophenyl)-2-phenylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC(=O)NC2=CC=CC(=C2)N

Technology Process of N-(3-aminophenyl)-2-phenylacetamide

There total 6 articles about N-(3-aminophenyl)-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-(3-nitrophenyl)-2-phenylacetamide (13140-76-6) → N-(3-aminophenyl)phenylacetamide (85856-32-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; under 2585.74 Torr;

DOI:10.1021/jm0602559

Reference yield:

3-nitro-aniline (99-09-2) → N-(3-aminophenyl)phenylacetamide (85856-32-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / pyridine / tetrahydrofuran / 2 h / 0 - 20 °C

2: 85 percent / H₂ / Pd/C / 2585.74 Torr

With pyridine; hydrogen; palladium on activated charcoal; In tetrahydrofuran;

DOI:10.1021/jm0602559

Reference yield:

phenylacetyl chloride (103-80-0) → N-(3-aminophenyl)phenylacetamide (85856-32-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / pyridine / tetrahydrofuran / 2 h / 0 - 20 °C

2: 85 percent / H₂ / Pd/C / 2585.74 Torr

With pyridine; hydrogen; palladium on activated charcoal; In tetrahydrofuran;

DOI:10.1021/jm0602559

upstream raw materials:

m-phenylenediamine

phenylacetyl chloride

N-(3-nitrophenyl)-2-phenylacetamide

3-nitro-aniline

Downstream raw materials:

2-Methyl-N-(3-phenylacetylamino-phenyl)-butyramide

2,2-Dimethyl-pentanoic acid (3-phenylacetylamino-phenyl)-amide

2,2-Dimethyl-N-(3-phenylacetylamino-phenyl)-propionamide

C₂₅H₂₄N₂O₂

Refernces

• 1、 Li, Pinglin,Fu, Lixue,Qiao, Yitao,Zhao, Jianxin,Wang, Wei,Yuan, Zhi. "Affinity adsorption mechanism studies of adsorbents C1-Zn(II) for uremic middle molecular peptides containing Asp-Phe-Leu-Ala-Glu sequence". experimental part. p. 375 - 379. Retrieved 2012/02/03.
• 2、 Sun, Aiming,Prussia, Andrew,Zhan, Weiqiang,Murray, Ernest E.,Doyle, Joshua,Cheng, Li-Ting,Yoon, Jeong-Joong,Radchenko, Eugene V.,Palyulin, Vladimir A.,Compans, Richard W.,Liotta, Dennis C.,Plemper, Richard K.,Snyder, James P.. "Nonpeptide inhibitors of measles virus entry". . p. 5080 - 5092. Retrieved 2007/10/03.