Silane, (1,1-dimethylethyl)[[(2R,3R,6R)-6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy] methyl]tetrahydro-2-(2Z)-2-tetradecenyl-2H-pyran-3-yl]oxy]diphenyl-

Base Information

Chemical Name:Silane, (1,1-dimethylethyl)[[(2R,3R,6R)-6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy] methyl]tetrahydro-2-(2Z)-2-tetradecenyl-2H-pyran-3-yl]oxy]diphenyl-
CAS No.:858645-40-6
Molecular Formula:C52H74O3Si2
Molecular Weight:803.329
Hs Code.:

Silane,
(1,1-dimethylethyl)[[(2R,3R,6R)-6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]
methyl]tetrahydro-2-(2Z)-2-tetradecenyl-2H-pyran-3-yl]oxy]diphenyl-

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Chemical Property of Silane, (1,1-dimethylethyl)[[(2R,3R,6R)-6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy] methyl]tetrahydro-2-(2Z)-2-tetradecenyl-2H-pyran-3-yl]oxy]diphenyl-

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Technology Process of Silane, (1,1-dimethylethyl)[[(2R,3R,6R)-6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy] methyl]tetrahydro-2-(2Z)-2-tetradecenyl-2H-pyran-3-yl]oxy]diphenyl-

There total 8 articles about Silane, (1,1-dimethylethyl)[[(2R,3R,6R)-6-[[[(1,1-dimethylethyl)diphenylsilyl]oxy] methyl]tetrahydro-2-(2Z)-2-tetradecenyl-2H-pyran-3-yl]oxy]diphenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 15510-55-1
dodecyltriphenylphosphonium bromide

: 837428-29-2
{(2R,3R,6R)-3-{[tert-butyl(diphenyl)silyl]oxy}-6-{[tert-butyl(diphenyl)silyl]oxymethyl}-tetrahydro-2H-pyran-2-yl}-acetic acid (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester

: 858645-40-6
(2R,3R,6R)-3-{[tert-butyl(diphenyl)silyl]oxy}-6-{[tert-butyl(diphenyl)silyl]oxymethyl}-2-[(Z)-tetradec-2-enyl]-tetrahydro-2H-pyran

: (2R,3R,6R)-3-{[tert-butyl(diphenyl)silyl]oxy}-6-{[tert-butyl(diphenyl)silyl]oxymethyl}-2-[(E)-tetradec-2-enyl]-tetrahydro-2H-pyran

Guidance literature:: {(2R,3R,6R)-3-{[tert-butyl(diphenyl)silyl]oxy}-6-{[tert-butyl(diphenyl)silyl]oxymethyl}-tetrahydro-2H-pyran-2-yl}-acetic acid (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester; With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 ℃; for 0.25h;

dodecyltriphenylphosphonium bromide; With sodium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; toluene; at -78 - 0 ℃; for 12h;
DOI:10.1021/jo052233k

Reference yield:

: 134341-56-3
meso-(2R,5S)-2,5-bis(tert-butyldiphenylsilyloxy)hexane-1,6-dial

: 858645-40-6
(2R,3R,6R)-3-{[tert-butyl(diphenyl)silyl]oxy}-6-{[tert-butyl(diphenyl)silyl]oxymethyl}-2-[(Z)-tetradec-2-enyl]-tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 7 steps

1.1: 77 percent / NaHMDS / tetrahydrofuran; toluene / 4 h / -78 °C

2.1: NaBH₄ / tetrahydrofuran; propan-2-ol / 3 h / 0 °C

3.1: DMAP / ethanol; various solvent(s) / 14 h / Heating

4.1: 95 percent / PPh₃; DIAD / toluene / 3 h / 20 °C

5.1: aq. LiOH / tetrahydrofuran / 2.5 h / 0 °C

5.2: t-BuOK / toluene / 0.83 h / 0 °C

6.1: t-BuOK / toluene / 0 °C

7.1: DIBAL-H / CH₂Cl₂; toluene / 0.25 h / -78 °C

7.2: 78 percent / NaHMDS / CH₂Cl₂; toluene; tetrahydrofuran / 12 h / -78 - 0 °C

With dmap; lithium hydroxide; sodium tetrahydroborate; di-isopropyl azodicarboxylate; potassium tert-butylate; sodium hexamethyldisilazane; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol; toluene; 1.1: Horner-Wadsworth-Emmons reaction / 4.1: Mitsunobu reaction / 7.2: Wittig reaction;
DOI:10.1021/jo052233k

Reference yield:

: 837428-48-5
(1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl (2Z,4R,7S)-4,8-bis{[tert-butyl(diphenyl)silyl]oxy}-8-oxooct-2-enoate

: 858645-40-6
(2R,3R,6R)-3-{[tert-butyl(diphenyl)silyl]oxy}-6-{[tert-butyl(diphenyl)silyl]oxymethyl}-2-[(Z)-tetradec-2-enyl]-tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaBH₄ / tetrahydrofuran; propan-2-ol / 3 h / 0 °C

2.1: DMAP / ethanol; various solvent(s) / 14 h / Heating

3.1: 95 percent / PPh₃; DIAD / toluene / 3 h / 20 °C

4.1: aq. LiOH / tetrahydrofuran / 2.5 h / 0 °C

4.2: t-BuOK / toluene / 0.83 h / 0 °C

5.1: t-BuOK / toluene / 0 °C

6.1: DIBAL-H / CH₂Cl₂; toluene / 0.25 h / -78 °C

6.2: 78 percent / NaHMDS / CH₂Cl₂; toluene; tetrahydrofuran / 12 h / -78 - 0 °C

With dmap; lithium hydroxide; sodium tetrahydroborate; di-isopropyl azodicarboxylate; potassium tert-butylate; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol; toluene; 3.1: Mitsunobu reaction / 6.2: Wittig reaction;
DOI:10.1021/jo052233k