2,2,2-trichloroethyl (6R,7R)-3-(bromomethyl)-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5-oxide

Base Information

Chemical Name:2,2,2-trichloroethyl (6R,7R)-3-(bromomethyl)-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5-oxide
CAS No.:33492-83-0
Molecular Formula:C16H14BrCl3N2O5S2
Molecular Weight:564.693
Hs Code.:

2,2,2-trichloroethyl (6R,7R)-3-(bromomethyl)-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5-oxide

Synonyms:

Suppliers and Price of 2,2,2-trichloroethyl (6R,7R)-3-(bromomethyl)-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5-oxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,2,2-trichloroethyl (6R,7R)-3-(bromomethyl)-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5-oxide

Chemical Property:

Vapor Pressure:2.79E-28mmHg at 25°C
Boiling Point:837.9°C at 760 mmHg
Flash Point:460.5°C
Density:1.86g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2,2,2-trichloroethyl (6R,7R)-3-(bromomethyl)-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5-oxide

There total 5 articles about 2,2,2-trichloroethyl (6R,7R)-3-(bromomethyl)-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 39098-97-0
2-thienylacetic acid chloride

: 85904-86-5
2,2,2-trichloroethyl (1S,6R,7R)-7-amino-3-bromomethylceph-3-em-4-carboxylate 1-oxide hydrobromide

: 33492-83-0
2,2,2-trichloroethyl (1S,6R,7R)-3-bromomethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide

Guidance literature:: With oxirane; In dichloromethane; for 0.0666667h;
DOI:10.1016/S0040-4020(01)88547-1

Reference yield:

: 33465-56-4
2,2,2-trichloroethyl (1S,6R,7R)-3-bromomethyl-7-formamidoceph-3-em-4-carboxylate 1-oxide

: 33492-83-0
2,2,2-trichloroethyl (1S,6R,7R)-3-bromomethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / phosphorus tribromide / methanol; diethyl ether / 1.17 h / 0 - 10 °C

2: 92 percent / ethylene oxide / CH₂Cl₂ / 0.07 h

With oxirane; phosphorus tribromide; In methanol; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4020(01)88547-1

Reference yield:

: 39098-97-0
2-thienylacetic acid chloride

: 33465-56-4
2,2,2-trichloroethyl (1S,6R,7R)-3-bromomethyl-7-formamidoceph-3-em-4-carboxylate 1-oxide

: 85904-87-6
2,2,2-trichloroethyl (1S,6R,7R)-3-chloromethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide

: 33492-83-0
2,2,2-trichloroethyl (1S,6R,7R)-3-bromomethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide

Guidance literature:: With ISOPROPYLAMIDE; trichlorophosphate; Yield given. Multistep reaction. Yields of byproduct given; 1.) MeOH, 45-55 deg C; 2.) CH₂Cl₂, 0-5 deg C, 45 min;
DOI:10.1016/S0040-4020(01)88547-1