2,2,2-trichloroethyl (1S,6R,7R)-3-chloromethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide

Base Information

Chemical Name:2,2,2-trichloroethyl (1S,6R,7R)-3-chloromethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide
CAS No.:85904-87-6
Molecular Formula:C₁₆H₁₄Cl₄N₂O₅S₂
Molecular Weight:520.242
Hs Code.:

Synonyms:2,2,2-trichloroethyl (1S,6R,7R)-3-chloromethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide

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Chemical Property of 2,2,2-trichloroethyl (1S,6R,7R)-3-chloromethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2,2,2-trichloroethyl (1S,6R,7R)-3-chloromethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide

There total 1 articles about 2,2,2-trichloroethyl (1S,6R,7R)-3-chloromethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 39098-97-0
2-thienylacetic acid chloride

: 33465-56-4
2,2,2-trichloroethyl (1S,6R,7R)-3-bromomethyl-7-formamidoceph-3-em-4-carboxylate 1-oxide

: 85904-87-6
2,2,2-trichloroethyl (1S,6R,7R)-3-chloromethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide

: 33492-83-0
2,2,2-trichloroethyl (1S,6R,7R)-3-bromomethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide

Guidance literature:: With ISOPROPYLAMIDE; trichlorophosphate; Yield given. Multistep reaction. Yields of byproduct given; 1.) MeOH, 45-55 deg C; 2.) CH₂Cl₂, 0-5 deg C, 45 min;
DOI:10.1016/S0040-4020(01)88547-1

Reference yield:

: 85904-87-6
2,2,2-trichloroethyl (1S,6R,7R)-3-chloromethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide

: 50-59-9
cefaloridine

Guidance literature:: Multi-step reaction with 3 steps

1: 67.3 percent / 1.5 h / 20 °C

2: 72.6 percent / phosphorus trichloride / CH₂Cl₂; dimethylformamide / 1.5 h / 21 °C

3: 1.) Zn, ZnCl₂; 2.) Deacidite FF ion-exchange resin / 1.) formic acid, 22 deg C, 2 h

With Deacidite FF ion-exchange resin; zinc(II) chloride; zinc; phosphorus trichloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)88547-1

Reference yield:

: 85904-87-6
2,2,2-trichloroethyl (1S,6R,7R)-3-chloromethyl-7-(thien-2-ylacetamido)ceph-3-em-4-carboxylate 1-oxide

: 153-61-7
cephalothin

Guidance literature:: Multi-step reaction with 4 steps

1: 66 percent / sodium iodide / acetone / 1.5 h

2: 50 percent / acetic acid / dimethylformamide / 3 h / 22 °C

3: 65 percent / potassium iodide, acetyl chloride / acetic acid / 0.17 h / 20 °C

4: 1.) Zn, ZnCl₂; 2.) Deacidite FF ion-exchange resin / 1.) formic acid, RT, 5 h

With Deacidite FF ion-exchange resin; acetic acid; acetyl chloride; potassium iodide; sodium iodide; zinc(II) chloride; zinc; In acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4020(01)88547-1