Benzenamine, N-[2-[(4-bromophenyl)thio]ethyl]-N-[2-[(tetrahydro-2H-pyran-2-yl)oxy]eth yl]-

Base Information

• Chemical Name: Benzenamine, N-[2-[(4-bromophenyl)thio]ethyl]-N-[2-[(tetrahydro-2H-pyran-2-yl)oxy]eth yl]-
• CAS No.: 861387-81-7
• Molecular Formula: C21H26BrNO2S
• Molecular Weight: 436.413
• Mol file: 861387-81-7.mol

Synonyms:

Chemical Property of Benzenamine, N-[2-[(4-bromophenyl)thio]ethyl]-N-[2-[(tetrahydro-2H-pyran-2-yl)oxy]eth yl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenamine, N-[2-[(4-bromophenyl)thio]ethyl]-N-[2-[(tetrahydro-2H-pyran-2-yl)oxy]eth yl]-

There total 4 articles about Benzenamine, N-[2-[(4-bromophenyl)thio]ethyl]-N-[2-[(tetrahydro-2H-pyran-2-yl)oxy]eth yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.7%

toluene-4-sulfonic acid 2-{phenyl-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-amino}-ethyl ester (861387-80-6) + para-bromobenzenethiol (106-53-6) → [2-(4-bromo-phenylsulfanyl)-ethyl]-phenyl-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-amine (861387-81-7)

Guidance literature:

para-bromobenzenethiol; With potassium carbonate; In acetone; for 1h; Heating;

toluene-4-sulfonic acid 2-{phenyl-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-amino}-ethyl ester; In acetone; for 12h; Heating;

DOI:10.1021/ol0507219

Reference yield:

{phenyl-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-amino}-ethanol (151514-10-2) → [2-(4-bromo-phenylsulfanyl)-ethyl]-phenyl-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-amine (861387-81-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 41.8 percent / pyridine / CH₂Cl₂ / 12 h / 20 °C

2.1: K₂CO₃ / acetone / 1 h / Heating

2.2: 91.7 percent / acetone / 12 h / Heating

With pyridine; potassium carbonate; In dichloromethane; acetone;

DOI:10.1021/ol0507219

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → [2-(4-bromo-phenylsulfanyl)-ethyl]-phenyl-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-amine (861387-81-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 51.1 percent / TsOH*H₂O / CH₂Cl₂ / 12 h / 20 °C

2.1: 41.8 percent / pyridine / CH₂Cl₂ / 12 h / 20 °C

3.1: K₂CO₃ / acetone / 1 h / Heating

3.2: 91.7 percent / acetone / 12 h / Heating

With pyridine; potassium carbonate; toluene-4-sulfonic acid; In dichloromethane; acetone;

DOI:10.1021/ol0507219

upstream raw materials:

toluene-4-sulfonic acid 2-{phenyl-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-amino}-ethyl ester

para-bromobenzenethiol

{phenyl-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-amino}-ethanol

3,4-dihydro-2H-pyran