106-53-6

Basic information

• Product Name: 4-Bromothiophenol
• Synonyms: Benzenethiol,p-bromo- (6CI,7CI,8CI);1-Bromo-4-mercaptobenzene;4-Bromobenzenethiol;4-Bromophenylthiol;NSC 229563;NSC 32018;p-Bromobenzenethiol;p-Bromophenyl thiol;p-Bromothiophenol;Benzenethiol, 4-bromo-
• CAS NO: 106-53-6
• Molecular Formula: C₆H₅BrS
• Molecular Weight: 189.0697
• EINECS: 203-407-3
• Product Categories: Phenyls & Phenyl-Het;Miscellaneous;Phenyls & Phenyl-Het;Phenol&Thiophenol&Mercaptan
• Mol File: 106-53-6.mol
• Article Data: 37

Chemical Properties

• Melting Point: 71-76℃
• Boiling Point: 231.3 °C at 760 mmHg
• Flash Point: 93.7 °C
• Appearance: White to light yellow crystal powder
• Density: 1.599 g/cm³
• Vapor Pressure: 0.0954mmHg at 25°C
• Storage Temp.: Refrigerator
• PKA: 6.08±0.10(Predicted)
• Water Solubility: Slightly soluble in water
• BRN: 507031
• CAS DataBase Reference: 4-Bromothiophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromothiophenol(106-53-6)
• EPA Substance Registry System: 4-Bromothiophenol(106-53-6)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:
• Safety Statements: S26:
• RIDADR: 2923
• WGK Germany: 3
• F: 10-13-23
• TSCA: T
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 106-53-6(Hazardous Substances Data)

Usage

Uses

4-Bromothiophenol is a reagent used in the synthesis of indolyl-3-ehtanone-α-thioethers which act as non-toxic antimalrial agents. These compounds show anti-malarial activity, with no toxicity to a HeLa cell line.

Chemical Properties

WHITE TO BEIGE CRYSTALS OR CRYSTALLINE POWDER

InChI:InChI=1/C6H5BrS/c7-5-1-3-6(8)4-2-5/h1-4,8H/p-1

Upstream product

• 722-27-0 bis(4-aminophenyl)disulfide 
• 126253-78-9 S-(4-Bromophenyl)mercapturic acid 
• 5335-84-2 bis(4-bromophenyl)disulfide 
• 3226-41-3 4-bromobenzenediazonium tetrafluoroborate 
• 60775-10-2 (4-bromo-phenyl)-(2,4-dinitro-phenyl)-sulfide 
• 68724-10-7 S-(4-bromo-phenyl)-cysteine 
• 108-98-5 thiophenol 
• 98-58-8 4-bromobenzenesulfonyl chloride 
• 123-75-1 pyrrolidine 
• 154393-31-4 (4-bromo-phenyl)-picryl sulfide 
• 110-89-4 piperidine 
• 106-37-6 1.4-dibromobenzene 
• 28122-76-1 acetyl 4-bromo-thiophenolate 
• 75168-73-9 4-bromobenzenesulfonyl chloride 

Downstream Products

• 6631-76-1 Piperidinomethyl-<4-brom-phenyl>-sulfid 
• 53136-21-3 1-benzylsulphanyl-4-bromobenzene 
• 63116-04-1 (4-bromo-phenyl)-(2-nitro-phenyl)-disulfide 
• 26732-20-7 4-bromo-(ethylsulfonyl)benzene 
• 223557-20-8 1-bromo-4-(propane-2-sulfonyl)benzene 
• 70399-02-9 1-bromo-4-(1-methylethylsulfonyl)benzene 
• 13735-04-1 3-(4-Bromophenylsulfanyl)propanoic Acid 
• 40897-58-3 1-(4-bromophenyl)-2-(4-nitrophenyl)disulfane 
• 403793-28-2 (4-bromo-phenyl)-butyl sulfone 
• 2393-98-8 1,1’-(methylenedisulfanediyl)bis(4-bromobenzene) 
• 18739-77-0 2-<(4-bromophenyl)thio>propionic acid 
• 856165-22-5 (4-bromo-phenyl)-hexyl sulfone 
• 99853-18-6 2-(4-bromo-phenylsulfanyl)-3-methyl-crotonaldehyde 
• 126253-78-9 S-(4-Bromophenyl)mercapturic acid 

Relevant articles and documents

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Synthesis of 4-hydroxy-l-thiacoumarins. 2

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SINGLE-STEP SYNTHESIS METHOD OF ARYL THIOL AND APPLICATION THEREOF

The present invention relates to a single-step synthesis method of aryl thiol, and more specifically, to a method of synthesizing aryl thiol in a single-step by making aryl halide react with alkane dithiol in the presence of a transition metal catalyst. According to the present invention, a single-step synthesis method using the transition metal catalyst, the synthesis method which is capable of synthesizing aryl thiol from aryl halide at a high yield, can be provided. Various aryl halides may be applied to the synthesis method. Further, the synthesis method has advantages that an easily usable reagent may be used, operations are simple, and reactions can be performed under mild conditions. In addition, the synthesized aryl thiol may be used in the synthesis of advanced molecules such as diaryl sulfides and benzothiophenes.COPYRIGHT KIPO 2017

The Chan-Lam reaction of chalcogen elements leading to aryl chalcogenides

A copper-catalyzed chalcogenation of arylboronic acids with elemental sulfur or selenium is established, which provides diaryl disulfides or diaryl monoselenides in moderate to good yields with excellent selectivities, respectively. Moreover, after sequential reduction and coupling with aryl/alkyl iodides in one pot, unsymmetrical monosulfides were obtained in good yields.