trans-4-Methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo(f)quinoline

Base Information

• Chemical Name: trans-4-Methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo(f)quinoline
• CAS No.: 1136-34-1
• Molecular Formula: C₁₄H₁₉N
• Molecular Weight: 201.312
• DSSTox Substance ID: DTXSID00921125
• Wikidata: Q76010278
• ChEMBL ID: CHEMBL3273262
• Mol file: 1136-34-1.mol

Synonyms:trans-4-Methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo(f)quinoline;1136-34-1;trans-4-methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinoline;SCHEMBL8172160;CHEMBL3273262;DTXSID00921125;CAIZFPWDMVYDRN-KBPBESRZSA-N;Benzo(f)quinoline, 1,2,3,4,4a,5,6,10b-octahydro-4-methyl-, trans-;4-Methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinoline

Chemical Property of trans-4-Methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo(f)quinoline

Chemical Property:

• Vapor Pressure: 0.00101mmHg at 25°C
• Boiling Point: 302.2°C at 760 mmHg
• Flash Point: 124.6°C
• Density: 1.01g/cm³
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 201.151749610
• Heavy Atom Count: 15
• Complexity: 225

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN1CCCC2C1CCC3=CC=CC=C23
• Isomeric SMILES: CN1CCC[C@@H]2[C@@H]1CCC3=CC=CC=C23

Technology Process of trans-4-Methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo(f)quinoline

There total 23 articles about trans-4-Methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo(f)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

<1'α(E),2'α>-(+/-)-3-<1',2',3',4'-tetrahydro-2'-(methylamino)-1'-naphthyl>prop-2-enyl acetate (113557-56-5,113557-57-6,113557-58-7,139184-71-7,139184-73-9,139184-74-0) → (+/-)-N-Methyl-cis-1,2,3,4,4a,5,6,10b-octahydro-benzochinolin (1136-33-0,1136-34-1,92849-92-8)

Guidance literature:

Multi-step reaction with 3 steps

1: conc. HCl / methanol

2: H₂ / PtO₂ / dioxane

3: SOCl₂

With hydrogenchloride; thionyl chloride; hydrogen; platinum(IV) oxide; In 1,4-dioxane; methanol;

Reference yield:

<1'α(Z),2'β>-(+/-)-3-<1',2',3',4'-tetrahydro-2'-(methylamino)-1'-naphthyl>prop-2-enyl acetate (113557-56-5,113557-57-6,113557-58-7,139184-71-7,139184-73-9,139184-74-0) → (+/-)-N-Methyl-trans-1,2,3,4,4a,5,6,10b-octahydro-benzochinolin (1136-33-0,1136-34-1,92849-92-8)

Guidance literature:

Multi-step reaction with 3 steps

1: conc. HCl / methanol

2: H₂ / PtO₂ / dioxane

3: SOCl₂

With hydrogenchloride; thionyl chloride; hydrogen; platinum(IV) oxide; In 1,4-dioxane; methanol;

Reference yield:

<1'α(E),2'β>-(+/-)-3-<1',2',3',4'-tetrahydro-2'-(methylamino)-1'-naphthyl>prop-2-enyl acetate (113557-56-5,113557-57-6,113557-58-7,139184-71-7,139184-73-9,139184-74-0) → (+/-)-N-Methyl-trans-1,2,3,4,4a,5,6,10b-octahydro-benzochinolin (1136-33-0,1136-34-1,92849-92-8)

Guidance literature:

Multi-step reaction with 3 steps

1: conc. HCl / methanol

2: H₂ / PtO₂ / dioxane

3: SOCl₂

With hydrogenchloride; thionyl chloride; hydrogen; platinum(IV) oxide; In 1,4-dioxane; methanol;

upstream raw materials:

trans-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinoline

methyl iodide

3-((1S,2S)-2-Methylamino-1,2,3,4-tetrahydro-naphthalen-1-yl)-propan-1-ol

<1'α(Z),2'β>-(+/-)-3-<1',2',3',4'-tetrahydro-2'-(methylamino)-1'-naphthyl>prop-2-enyl acetate

Refernces

• 1、 Smissman et al.. "Syntheses of cisoid and transoid analogs of phenethylamine.". . p. 109,112. Retrieved 2007/10/04.