Benzene, 1,4-dibromo-2-(dimethoxymethyl)-3-fluoro-

Base Information

Chemical Name:Benzene, 1,4-dibromo-2-(dimethoxymethyl)-3-fluoro-
CAS No.:861928-18-9
Molecular Formula:C9H9Br2FO2
Molecular Weight:327.976
Hs Code.:
DSSTox Substance ID:DTXSID60479677
Nikkaji Number:J2.196.133G
Wikidata:Q82313822

Synonyms:Benzene, 1,4-dibromo-2-(dimethoxymethyl)-3-fluoro-;861928-18-9;DTXSID60479677

Suppliers and Price of Benzene, 1,4-dibromo-2-(dimethoxymethyl)-3-fluoro-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzene, 1,4-dibromo-2-(dimethoxymethyl)-3-fluoro-

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:327.89328
Heavy Atom Count:14
Complexity:178

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(C1=C(C=CC(=C1F)Br)Br)OC

Technology Process of Benzene, 1,4-dibromo-2-(dimethoxymethyl)-3-fluoro-

There total 2 articles about Benzene, 1,4-dibromo-2-(dimethoxymethyl)-3-fluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 870703-68-7
3,6-dibromo-2-fluorobenzaldehyde

: 149-73-5
trimethyl orthoformate

: 861928-18-9
1,4-dibromo-2-(dimethoxymethyl)-3-fluorobenzene

Guidance literature:: With sulfuric acid; In methanol; at 60 ℃; for 1h;
DOI:10.1016/j.tet.2005.04.051

Reference yield:

: 1435-52-5
2,5-dibromofluorobenzene

: 861928-18-9
1,4-dibromo-2-(dimethoxymethyl)-3-fluorobenzene

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / TMP; BuLi / tetrahydrofuran; diethyl ether / -78 °C

2: 99 percent / H₂SO₄ / methanol / 1 h / 60 °C

With n-butyllithium; sulfuric acid; thymidine 5'-phosphate; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1016/j.tet.2005.04.051

Reference yield: 48.0%

: 861928-18-9
1,4-dibromo-2-(dimethoxymethyl)-3-fluorobenzene

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 4-bromo-1,3-diformyl-2-fluorobenzene

Guidance literature:: 1,4-dibromo-2-(dimethoxymethyl)-3-fluorobenzene; With n-butyllithium; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.25h;

N,N-dimethyl-formamide; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.25h;
DOI:10.1016/j.tet.2005.04.051