4(3H)-Quinazolinone, 2-methyl-3-[4-[3-(1-pyrrolidinyl)propoxy]phenyl]-5-(trifluoromethyl)-

Base Information

Chemical Name:4(3H)-Quinazolinone, 2-methyl-3-[4-[3-(1-pyrrolidinyl)propoxy]phenyl]-5-(trifluoromethyl)-
CAS No.:862309-06-6
Molecular Formula:C23H24F3N3O2
Molecular Weight:431.458
Hs Code.:

Synonyms:2-methyl-3-{4-[3-(1-pyrrolidinyl)propoxy]phenyl}-5-trifluoromethyl-4(3H)-quinazolinone;2-methyl-(3-{4-[3-(1-pyrrolidinyl)propoxy]phenyl}-5-trifluoromethyl-4(3H)-quinazolinone);

Suppliers and Price of 4(3H)-Quinazolinone, 2-methyl-3-[4-[3-(1-pyrrolidinyl)propoxy]phenyl]-5-(trifluoromethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
MK-0249 99.53%
5mg
$ 1950.00

ChemScene
MK-0249 99.53%
1mg
$ 696.00

Total 3 raw suppliers

Chemical Property of 4(3H)-Quinazolinone, 2-methyl-3-[4-[3-(1-pyrrolidinyl)propoxy]phenyl]-5-(trifluoromethyl)-

Chemical Property:

PSA：47.36000
LogP:4.51550

Purity/Quality:

97% ^*data from raw suppliers

MK-0249 99.53% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4(3H)-Quinazolinone, 2-methyl-3-[4-[3-(1-pyrrolidinyl)propoxy]phenyl]-5-(trifluoromethyl)-

There total 4 articles about 4(3H)-Quinazolinone, 2-methyl-3-[4-[3-(1-pyrrolidinyl)propoxy]phenyl]-5-(trifluoromethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 862310-31-4
2-methyl-5-(trifluoromethyl)-4H-3,1-benzoxazin-4-one

: 1-{3-[(4-aminophenyl)oxy]propyl}pyrrolidine ditosylate

: 862309-06-6
2-methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-5-(trifluoromethyl)-4(3H)-quinazolinone

Guidance literature:: 2-methyl-5-(trifluoromethyl)-4H-3,1-benzoxazin-4-one; 1-{3-[(4-aminophenyl)oxy]propyl}pyrrolidine ditosylate; sodium acetate; acetic acid; In tetrahydrofuran; at 30 ℃; for 50h;

In n-heptane; toluene; at 0 - 50 ℃; for 8.8h; Product distribution / selectivity; Seed crystal of product addition;

Reference yield: 70.0%

: 1-{3-[(4-aminophenyl)oxy]propyl}pyrrolidine ditosylate

: 2-methyl-5-(trifluoromethyl)-4H-3,1-benzoxazin-4-one

: 862309-06-6
2-methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-5-(trifluoromethyl)-4(3H)-quinazolinone

Guidance literature:: With sodium acetate; acetic acid; In tetrahydrofuran; at 40 ℃; for 72h;
DOI:10.1021/jm8003834

Reference yield: 55.0%

: 862310-31-4
2-methyl-5-(trifluoromethyl)-4H-3,1-benzoxazin-4-one

: 343965-79-7
1-{3-[(4-aminophenyl)oxy]propyl}pyrrolidine

: 862309-06-6
2-methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-5-(trifluoromethyl)-4(3H)-quinazolinone

Guidance literature:: 2-methyl-5-(trifluoromethyl)-4H-3,1-benzoxazin-4-one; 1-{3-[(4-aminophenyl)oxy]propyl}pyrrolidine; In acetic acid; at 20 - 50 ℃; for 26h;

With citric acid; In water; ethyl acetate;

With sodium hydroxide; In water; pH=10 - 11;