6-Chloro-5-formyl-1,3-dimethyluracil

Base Information

• Chemical Name: 6-Chloro-5-formyl-1,3-dimethyluracil
• CAS No.: 35824-85-2
• Molecular Formula: C7H7ClN2O3
• Molecular Weight: 202.597
• Hs Code.: 2933990090
• Mol file: 35824-85-2.mol

Synonyms:6-Chloro-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbaldehyde;6-chloro-5-formyl-N,N-dimethyluracil;6-chloro-1,2,3,4,-tetrahydro-1,3-dimethyl-2,4-dioxo-5-pyrimidinecarboxaldehyde;6-chloro-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxaldehyde;6-Chloro-5-formyl-1,3-dimethyluracil;

Chemical Property of 6-Chloro-5-formyl-1,3-dimethyluracil

Chemical Property:

• Vapor Pressure: 0.00891mmHg at 25°C
• Boiling Point: 265.9°Cat760mmHg
• Flash Point: 114.6°C
• PSA: 61.07000
• Density: 1.49g/cm³
• LogP: -0.45010

Purity/Quality:

98%min ^*data from raw suppliers

6-Chloro-5-formyl-1,3-dimethyluracil ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Chloro-5-formyl-1,3-dimethyluracil

There total 2 articles about 6-Chloro-5-formyl-1,3-dimethyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1,3-dimethylbarbituric acid (769-42-6) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 6-chloro-5-formyl-1,3-dimethyluracil (35824-85-2)

Guidance literature:

With trichlorophosphate;

DOI:10.1016/S0040-4039(00)61393-X

Reference yield:

→ 6-chloro-5-formyl-1,3-dimethyluracil (35824-85-2)

Guidance literature:

Reference yield: 95.0%

N-allyl-N-phenylamine (589-09-3) + 6-chloro-5-formyl-1,3-dimethyluracil (35824-85-2) → 6-(Allyl-phenyl-amino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde (114143-07-6)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h;

DOI:10.3762/bjoc.6.11

upstream raw materials:

1,3-dimethylbarbituric acid

N,N-dimethyl-formamide

Downstream raw materials:

6-(Furan-2-ylmethyl-p-tolyl-amino)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde

6-[(4-Chloro-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde

6-[Furan-2-ylmethyl-(4-methoxy-phenyl)-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde

6-[(4-Methoxy-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde

Refernces

• 1、 -. "PYRIMIDINEDIONE-FUSED HETEROCYCLIC COMPOUNDS AS TRPA1 MODULATORS". Page/Page column 37. . Retrieved 2010/11/17.
• 2、 Prajapati, Dipak,Sandhu, Jagir Singh. "Studies on Pyrimidine-Annelated Heterocycles; 8. Intramolecular Cycloaddition of Thiophene and Nitrile Oxide or Nitrone Groups Bonded to 1,3-Dimethyluracils". . p. 342 - 344. Retrieved 2007/10/02.