6-[(4-Chloro-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde

Base Information

Chemical Name:6-[(4-Chloro-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde
CAS No.:116360-58-8
Molecular Formula:C₁₈H₁₆ClN₃O₃S
Molecular Weight:389.862
Hs Code.:

Synonyms:6-[(4-Chloro-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde

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Chemical Property of 6-[(4-Chloro-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde

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Technology Process of 6-[(4-Chloro-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde

There total 1 articles about 6-[(4-Chloro-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 116055-27-7
4-chloro-N-(thien-2-ylmethyl)aniline

: 35824-85-2
6-chloro-5-formyl-1,3-dimethyluracil

: 116360-58-8
6-[(4-Chloro-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde

Guidance literature:: With triethylamine; In dichloromethane; for 12h; Ambient temperature;
DOI:10.1055/s-1988-27568

Reference yield: 61.0%

: 116360-58-8
6-[(4-Chloro-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde

: 116316-93-9
6-[(4-Chloro-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde oxime

Guidance literature:: With sodium hydroxide; hydroxylamine hydrochloride; In ethanol; for 4h; Ambient temperature;
DOI:10.1055/s-1988-27568

Reference yield:

: 116360-58-8
6-[(4-Chloro-phenyl)-thiophen-2-ylmethyl-amino]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde

: 116316-98-4
11-(4-Chloro-phenyl)-1,3-dimethyl-10,11-dihydro-1H,6aH-6-oxa-9-thia-1,3,5,11-tetraaza-pentaleno[1,6a-a]naphthalene-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / NH₂OH*HCl, aq. NaOH / ethanol / 4 h / Ambient temperature

2: 75 percent / Et₃N, 10percent aq. NaOCl / CH₂Cl₂ / 3 h / 0 - 10 °C

With sodium hydroxide; sodium hypochlorite; hydroxylamine hydrochloride; triethylamine; In ethanol; dichloromethane;
DOI:10.1055/s-1988-27568