4-amino-N-(4-methoxyphenyl)benzamide

Base Information

• Chemical Name: 4-amino-N-(4-methoxyphenyl)benzamide
• CAS No.: 891-35-0
• Molecular Formula: C14H14N2O2
• Molecular Weight: 242.277
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID40355066
• Nikkaji Number: J2.669.901K
• Wikidata: Q82133681
• Mol file: 891-35-0.mol

Synonyms:4-amino-N-(4-methoxyphenyl)benzamide;891-35-0;4-Amino-N-(4-methoxy-phenyl)-benzamide;Benzamide, 4-amino-N-(4-methoxyphenyl)-;MFCD00578773;ZINCSULFAMATE;Oprea1_040385;SCHEMBL11462217;DTXSID40355066;BBL028775;STK833185;AKOS000115416;SB76989;AS-31717;SY018392;FT-0703458;EN300-02323;AE-641/04209018;SR-01000200931;J-514443;SR-01000200931-1;Z56792373

Chemical Property of 4-amino-N-(4-methoxyphenyl)benzamide

Chemical Property:

• Vapor Pressure: 2.26E-05mmHg at 25°C
• Boiling Point: 360.2°C at 760 mmHg
• Flash Point: 171.6°C
• PSA: 64.35000
• Density: 1.245g/cm³
• LogP: 3.18390
• Storage Temp.: 2-8°C
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 242.105527694
• Heavy Atom Count: 18
• Complexity: 267

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-n-(4-methoxyphenyl)benzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)NC(=O)C2=CC=C(C=C2)N

Technology Process of 4-amino-N-(4-methoxyphenyl)benzamide

There total 6 articles about 4-amino-N-(4-methoxyphenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.8%

4-methoxy-aniline (104-94-9) + 4-aminobenzoyl chloride (16106-38-0) → 4-amino-N-(4-methoxyphenyl)benzamide (891-35-0)

Guidance literature:

With triethylamine; In dichloromethane;

Reference yield: 79.4%

→ 4-amino-N-(4-methoxyphenyl)benzamide (891-35-0)

Guidance literature:

With iron; ammonium chloride; In methanol; water; at 70 ℃; for 5h;

Reference yield:

4-methoxy-aniline (104-94-9) → 4-amino-N-(4-methoxyphenyl)benzamide (891-35-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C

2: palladium on activated charcoal; hydrogen / ethyl acetate / 1 h / 1500.15 Torr

With palladium on activated charcoal; hydrogen; triethylamine; In dichloromethane; ethyl acetate;

DOI:10.1055/s-0032-1323759

upstream raw materials:

4-methoxy-aniline

4-nitro-benzoyl chloride

4-nitro-benzoic acid

4-amino-benzoic acid

Downstream raw materials:

4-[(1,1-dioxidobenzo[d]isothiazol-3-yl)amino]-N-(4-methoxyphenyl)benzamide

Refernces

• 1、 Adel, Mai,Serya, Rabah A.T.,Lasheen, Deena S.,Abouzid, Khaled A.M.. "Identification of new pyrrolo[2,3-d]pyrimidines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, biological evaluation and molecular modeling". . p. 612 - 629. Retrieved 2018/09/29.
• 2、 -. "2-phenylpyrimidine compounds, preparation method and medical application". Paragraph 0098; 0099; 0124; 0125; 0126. . Retrieved 2018/06/15.