Pyrrolidine, 2-[diphenyl[(triethylsilyl)oxy]methyl]-, (2S)-

Base Information

Chemical Name:Pyrrolidine, 2-[diphenyl[(triethylsilyl)oxy]methyl]-, (2S)-
CAS No.:864466-70-6
Molecular Formula:C₂₃H₃₃NOSi
Molecular Weight:367.607
Hs Code.:
DSSTox Substance ID:DTXSID70478994
Nikkaji Number:J2.212.712H
Wikidata:Q82312805
Mol file:864466-70-6.mol

Synonyms:864466-70-6;Pyrrolidine, 2-[diphenyl[(triethylsilyl)oxy]methyl]-, (2S)-;(S)-2-(Diphenyl((triethylsilyl)oxy)methyl)pyrrolidine;[diphenyl-[(2S)-pyrrolidin-2-yl]methoxy]-triethylsilane;(2S)-2-[Diphenyl[(triethylsilyl)oxy]methyl]pyrrolidine;DTXSID70478994;AKOS028109137

Suppliers and Price of Pyrrolidine, 2-[diphenyl[(triethylsilyl)oxy]methyl]-, (2S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(S)-2-(Diphenyl((triethylsilyl)oxy)methyl)pyrrolidine 97%
250mg
$ 272.00

Crysdot
(S)-2-(Diphenyl((triethylsilyl)oxy)methyl)pyrrolidine 97%
1g
$ 680.00

Chemenu
(S)-2-(diphenyl((triethylsilyl)oxy)methyl)pyrrolidine 97%
1g
$ 636.00

Alichem
(S)-2-(Diphenyl((triethylsilyl)oxy)methyl)pyrrolidine
1g
$ 727.60

Total 7 raw suppliers

Chemical Property of Pyrrolidine, 2-[diphenyl[(triethylsilyl)oxy]methyl]-, (2S)-

Chemical Property:

Boiling Point:453.4±35.0 °C(Predicted)
PKA:10.10±0.10(Predicted)
Density:0.998±0.06 g/cm3(Predicted)
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:8
Exact Mass:367.233141211
Heavy Atom Count:26
Complexity:384

Purity/Quality:

98%,99%, ^*data from raw suppliers

(S)-2-(Diphenyl((triethylsilyl)oxy)methyl)pyrrolidine 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC[Si](CC)(CC)OC(C1CCCN1)(C2=CC=CC=C2)C3=CC=CC=C3
Isomeric SMILES:CC[Si](CC)(CC)OC([C@@H]1CCCN1)(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of Pyrrolidine, 2-[diphenyl[(triethylsilyl)oxy]methyl]-, (2S)-

There total 4 articles about Pyrrolidine, 2-[diphenyl[(triethylsilyl)oxy]methyl]-, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 22348-32-9,63401-04-7,112022-88-5,112068-01-6
(S)-diphenylprolinol

: 79271-56-0
triethylsilyl trifluoromethyl sulfonate

: 864466-70-6
(S)-2-(diphenyl((triethylsilyl)oxy)methyl)pyrrolidine

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; for 8h;
DOI:10.1002/anie.200500599

Reference yield:

: 617-86-7
triethylsilane

: 22348-32-9,63401-04-7,112022-88-5,112068-01-6
(S)-diphenylprolinol

: 864466-70-6
(S)-2-(diphenyl((triethylsilyl)oxy)methyl)pyrrolidine

Guidance literature:: With 2,3-Dihydro-1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene; In acetonitrile; at 50 ℃; for 19h; chemoselective reaction; Glovebox; Inert atmosphere; Schlenk technique;
DOI:10.1002/chem.201301893

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 864466-70-6
(S)-2-(diphenyl((triethylsilyl)oxy)methyl)pyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium; iodine / tetrahydrofuran / 1.33 h / Inert atmosphere; Reflux

1.2: 2.25 h / 20 °C / Inert atmosphere

2.1: sodium hydroxide / ethanol / 1 h / Reflux

3.1: triethylamine / dichloromethane / 3.5 h / -78 - 20 °C / Inert atmosphere

With iodine; magnesium; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/acs.joc.5b00380