1-Pyrrolidinecarboxylic acid, 2-(hydroxydiphenylmethyl)-,1,1-dimethylethyl ester, (2R)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-(hydroxydiphenylmethyl)-,1,1-dimethylethyl ester, (2R)-
CAS No.:137496-68-5
Molecular Formula:C22H27NO3
Molecular Weight:353.461
Hs Code.:
Mol file:137496-68-5.mol

Synonyms:tert-butyl (S)-(-)-2-(hydroxy(diphenyl)methyl)-1-pyrrolidine carboxylate;2-[hydroxy(diphenyl)methyl]pyrrolidine-1-carboxylic acid tert-butyl ester;

Suppliers and Price of 1-Pyrrolidinecarboxylic acid, 2-(hydroxydiphenylmethyl)-,1,1-dimethylethyl ester, (2R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-(hydroxydiphenylmethyl)-,1,1-dimethylethyl ester, (2R)-

Chemical Property:

PSA：49.77000
LogP:4.25990

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Pyrrolidinecarboxylic acid, 2-(hydroxydiphenylmethyl)-,1,1-dimethylethyl ester, (2R)-

There total 18 articles about 1-Pyrrolidinecarboxylic acid, 2-(hydroxydiphenylmethyl)-,1,1-dimethylethyl ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 137496-68-5
2-[hydroxy(diphenyl)methyl]pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield: 83.0%

: 100-59-4
phenylmagnesium chloride

: 59936-29-7
(S)-N-(tert-butoxycarbonyl)proline methyl ester

: 137496-68-5
2-[hydroxy(diphenyl)methyl]pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1002/ejoc.201701603

Reference yield: 82.0%

: 119-61-9
benzophenone

: 86953-79-9
tert-butyl pyrrolidine-1-carboxylate

: 137496-68-5
2-[hydroxy(diphenyl)methyl]pyrrolidine-1-carboxylic acid tert-butyl ester

: 137496-68-5
2-(hydroxy(diphenyl)methyl)pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: tert-butyl pyrrolidine-1-carboxylate; With sec.-butyllithium; (1R,5S,11aS)-3-methyldecahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocine; In diethyl ether; at -30 ℃; for 0.0333333h;

benzophenone; In diethyl ether; Reagent/catalyst; Temperature; Time; Overall yield = 56 %; enantioselective reaction;
DOI:10.1021/ol402395j