ChloraMphenicol 2-(O-tert-ButyldiMethylsilyl)Methyl 1-Acetate

Base Information

• Chemical Name: ChloraMphenicol 2-(O-tert-ButyldiMethylsilyl)Methyl 1-Acetate
• CAS No.: 864529-27-1
• Molecular Formula: C19H28Cl2N2O6Si
• Molecular Weight: 479.433
• Mol file: 864529-27-1.mol

Synonyms:(1S,2R)-3-((tert-butyldimethylsilyl)oxy)-2-(2,2-dichloroacetamido)-1-(4-nitrophenyl)propyl acetate;

Chemical Property of ChloraMphenicol 2-(O-tert-ButyldiMethylsilyl)Methyl 1-Acetate

Chemical Property:

• PSA: 110.45000
• LogP: 5.42340
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

Chloramphenicol2-(O-tert-Butyldimethylsilyl)methyl1-Acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: ChloraMphenicol 2-(O-tert-ButyldiMethylsilyl)Methyl 1-Acetate is used in the preparation of Azithromycin (A927000) compounds as antibacterial, anti-proliferative, and antiinflammatory agents.

Technology Process of ChloraMphenicol 2-(O-tert-ButyldiMethylsilyl)Methyl 1-Acetate

There total 4 articles about ChloraMphenicol 2-(O-tert-ButyldiMethylsilyl)Methyl 1-Acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

acetic anhydride (108-24-7) + chloramphenicol (864529-25-9) → (1R,2R)-3-((tert-butyldimethylsilyl)oxy)-2-(2,2-dichloroacetamido)-1-(4-nitrophenyl)propyl acetate (864529-27-1)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1021/acs.jnatprod.7b00903

Reference yield: 90.0%

chloramphenicol (56-75-7,85666-84-8) + acetic anhydride (108-24-7) + tert-butyldimethylsilyl chloride (18162-48-6) → (1R,2R)-3-((tert-butyldimethylsilyl)oxy)-2-(2,2-dichloroacetamido)-1-(4-nitrophenyl)propyl acetate (864529-27-1)

Guidance literature:

chloramphenicol; tert-butyldimethylsilyl chloride; With 1H-imidazole; In dichloromethane; at 25 ℃; for 0.5h;

acetic anhydride; With triethylamine; In dichloromethane; at 25 ℃; for 12h;

DOI:10.1016/j.bmc.2015.04.069

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → (1R,2R)-3-((tert-butyldimethylsilyl)oxy)-2-(2,2-dichloroacetamido)-1-(4-nitrophenyl)propyl acetate (864529-27-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-imidazole / dichloromethane / 2 h

2: pyridine / dichloromethane / 4 h / 20 °C

With pyridine; 1H-imidazole; In dichloromethane;

DOI:10.1021/acs.jnatprod.7b00903

upstream raw materials:

acetic anhydride

chloramphenicol

chloramphenicol

tert-butyldimethylsilyl chloride

Downstream raw materials:

(1R,2R)-2-[(dichloroacetyl)amino]-3-hydroxy-1-(4-nitrophenyl)propyl acetate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 864529-27-1 ChloraMphenicol 2-(O-tert-ButyldiMethylsilyl)Methyl 1-Acetate

Send

Send

Metric Ton KG G Pound L ML

Send

Send