CFMTI

Base Information

• Chemical Name: CFMTI
• CAS No.: 864864-17-5
• Molecular Formula: C₁₉H₁₆FN₅O
• Molecular Weight: 349.367
• Mol file: 864864-17-5.mol

Synonyms:

Chemical Property of CFMTI

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

CFMTI ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: CFMTI is an allosteric metabotropic glutamate receptor 1 antagonist with antipsychotic activity that induces Fos expression in various regions of the brain.

Technology Process of CFMTI

There total 4 articles about CFMTI which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-cyclopropylisoindolin-1-one (864866-56-8) + 1-(2-fluoro-3-pyridyl)-5-methyl-4-(tri-n-butylstannyl)-1H-1,2,3-triazole (864866-09-1) → CFMTI (864864-17-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 115 ℃;

DOI:10.1016/j.bmcl.2009.07.145

Reference yield:

2-fluoropyridine (372-48-5) → CFMTI (864864-17-5)

Guidance literature:

Multi-step reaction with 3 steps

1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.25 h / -78 - 0 °C

2: toluene / 3 h / 120 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / Heating / reflux

With n-butyllithium; diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; toluene; 3: Stille Coupling;

Reference yield:

4-bromo-2-(bromomethyl)benzoic acid (632340-57-9) → CFMTI (864864-17-5)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / toluene / Heating / reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / Heating / reflux

With triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; 2: Stille Coupling;

upstream raw materials:

5-bromo-2-cyclopropylisoindolin-1-one

1-(2-fluoro-3-pyridyl)-5-methyl-4-(tri-n-butylstannyl)-1H-1,2,3-triazole

3-azido-2-fluoropyridine

2-fluoropyridine