Chemical Property of 2'-Deoxy-5-chlorouridine
Chemical Property:
- Melting Point:176-179°C
- Refractive Index:1.6500 (estimate)
- Boiling Point:°Cat760mmHg
- PKA:7.73±0.10(Predicted)
- Flash Point:°C
- PSA：104.55000
- Density:1.67 g/cm3
- LogP:-1.16930
- Storage Temp.:−20°C
- Solubility.:DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- XLogP3:-0.7
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:2
- Exact Mass:262.0356491
- Heavy Atom Count:17
- Complexity:386
- Purity/Quality:
-
99%, *data from raw suppliers
5-Chloro-2''-deoxyuridine *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
20/21/22-40
- Safety Statements:
36/37/39-45
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:C1C(C(OC1N2C=C(C(=O)NC2=O)Cl)CO)O
- Isomeric SMILES:C1[C@@H]([C@H](O[C@@H]1N2C=C(C(=O)NC2=O)Cl)CO)O
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Description
5-Chloro-2''-deoxyuridine (CldU) is a thymidine analog that is readily incorporated, following phosphorylation, into newly synthesized DNA in place of thymidine. Like 5-bromo-2’-deoxyuridine and 5-iodo-2’-deoxyuridine, CldU can be detected immunologically in cells and tissues. CldU can also be added to cells or tissues sequentially with another thymidine analog to label temporally distinct populations. The insertion of thymidine analogs, including CldU, can significantly alter DNA processing and replication, so these analogs have also been used as mutagens, clastogens, and antiviral compounds.
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Uses
A halogenated uridine derivative used in pharmaceutical compositions. 5-Chloro-2'-deoxyuridine (CldU) is a thymidine analog that is readily incorporated, following phosphorylation, into newly synthesized DNA in place of thymidine. Like 5-bromo-2’-deoxyuridine and 5-iodo-2’-deoxyuridine, CldU can be detected immunologically in cells and tissues. CldU can also be added to cells or tissues sequentially with another thymidine analog to label temporally distinct populations. The insertion of thymidine analogs, including CldU, can significantly alter DNA processing and replication, so these analogs have also been used as mutagens, clastogens, and antiviral compounds.[Cayman Chemical] 5-Chloro-2′-deoxyuridine (CldU) is used as a thymidine analog to study the miscoding potential of hypochlorous acid damage to DNA and DNA precursors. When used with antibody based immunofluorescent imaging, 5-Chloro-2′-deoxyuridine incorporation may be used in protocols to identify sites of DNA replication. CldU may be used as a labeling substrate in conjunction with other halogenated uridine labeling substrates such as iododeoxyuridine (IdU).
